中国科学院：Astrocytic L-Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision
by 管理员 | 2018-01-11
Prof. WANG Liping and Prof. TU Jie from Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy ofSciences, collaborating with researchers from City University of Hong Kong,recently discovered a new role of astrocytes in one of the basic cognitivefunctions - decision making.
Their findings, published in Cell Reports,could lead to new insights into functions of neuroglia cells in the cognitionbehavior.
The research team led by Prof. LI Ying fromCity University of Hong Kong provided an elegant cognition measurementmodelgambling test.
Based on this model, they demonstrated thatimpairment of decision making is associated with suppressed synchronization inbasolateral amygdala (BLA) - the anterior cingulate cortex (ACC) network in thechronic pain rat models.
Prof. WANG Liping's team from SIAT is apioneer group of optogentics in China. Through joint tackling, they found thatthe repairing effect of "astrocyte-neuronal L-lactate shuttle" on theimpaired cognitive function: optogenetic activation of ACC astrocytes triggerslocal lactate release, which contributesto the rescue of BLA-ACC synchrony and decision-making performance in chronicpain rats.
Their findings proposed a new model forlinking the basic neural cells metabolism function and advanced cognitivefunction.
Also, their findings provide new insightsinto cognitive and pain treatment in clinical chronic pain management.
Impairment of decision making is associated with suppressed synchronization in basolateral amygdala (BLA) in the chronic pain rat models.