ResearchDefensive behavior is essential for the survival of all species. Epilepsy is a circuit-level dysfunction which affects nearly 1% of total population worldwide. Epilepsy induced impairment of defensive responses is associated with high rates of premature mortality from external causes, but the underlying mechanisms is still unknown. We perform precisely timed and cell type-specific in vivo optogenetic methodologies in freely moving epileptic animals to clarify the neural circuit mechanisms for the influence of epilepsy on defensive behaviors and to identify the potential cell specific intervention targets for epilepsy-induced disorders. Technology tools, such as electrophysiological recording, optogenetics and trans-synaptic tracing technique, improve neural circuits research. We mainly focus on: designing and modifying novel optrode (electrode) array; dissecting defensive behavior related neural circuit and discriminating the circuit function in epileptic animal model.
Biography2018-present, associated investigator at SIAT, CAS 2018, assistant investigator 2014-2017, University of the Chinese Academy of Sciences, PhD 2011-2013, research assistant 2009-2011, Wuhan University, Master 2005-2009, Henan University of Technology, B.S
Selected publications1.Wang LL#, Zhong C#, Ke DN, Ye FM, Tu J, Wang LP*, LuYi*, Ultrasoft and highly stretchable hydrogel optical fibers for in vivo optogenetic modulations. Advanced optical materials, 2018:6:1800427. (#co-first author) 2.Zhong C, Ke DN, Wang LL, Lu Y*, Wang LP*, Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface. Electrochemistry Communications, 2017:79:59-62. 3.Lu Y#, Zhong C#, Wang LL, Wei PF, He W, Huang K, Zhang Y, Zhan Y, Feng GP, Wang LP*, Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures. Nature Communications, 2016:7:10962. (#co-first author) 4.Zhong C#, Zhang YY#, He W, Wei PF, Lu Y, Zhu Y, Liu L, Wang LP*. Multi-unit recording with iridium oxide modified stereotrodes in Drosophila melanogaster, Journal of Neuroscience Methods. 2014;222:218-29. (#co-first author) 5.Wang LL#, Huang K#,Zhong C, Wang LP*, Lu Y*, Fabrication and modification of implantable optrode arrays for in vivo optogenetic applications. Biophysics Reports, 2018; 4: 82-93. (Cover Story) (#co-first author) 6.Liu YH#, Li J#,Zhong C, Tang YQ , Lu Y*, optrode arrays for multi-circuit dissection. Journal of integration technology. Nov. 2015. (#co-first author)