WANG Feng

WANG Feng

M.D, Ph.D, Associate Investigator
Investigates the neural circuit mechanisms of sex differences in emotion and behavior.
Office Phone: 
86-755-86531448

Research

A major challenge in neuroscience lies in understanding how sex differences in the brain, from molecules to circuits, synergistically contribute to sex differences in behavioral displays. All animals have evolved a repertoire of innate behaviors, whilst most of these behaviors display robust sexual dimorphism. Furthermore, many neuro-psychiatric disorders exhibit sex differences in incidence or disease outcomes. Earlier evidence indicate endocannabinoid (eCB) system in brain is organized differently in male and female, and this system is involved in the regulations of innate behaviors, such as feeding and sleep, and that of common neuro-psychiatric illnesses. Therefore, our current interests will focus on using state-of-the-art genetic and optogenetic tools to reveal (1) how eCB system-modulated sex differences in the brain underlies the sexual dimorphisms in innate behavior such as innate fear, arousal and sleep; (2) the role of eCB system in the neural circuitry contributing to the sexually dimorphic neuro-psychiatric disorders.

王枫,博士,副研究员。主要研究方向:综合运用基于机器学习的精细行为分析、神经环路示踪与调控技术来揭示:①本能行为的性别差异性特征及其神经环路机制;②不同脑状态下本能行为变异及其神经机制。主持科技创新2030—“脑科学与类脑研究”青年科学家项目(2022年~2026年),发表SCI收录论文32篇,其中通讯作者(含共同)论文10篇。 


Positions available in Wang Lab at SIAT
The lab is interested in recruiting highly motivated Postdoctoral Research Fellows to study the underlying neural circuitry mechanisms in innate behaviors and brain disorders. Candidates shall send their CV to feng.wang@siat.ac.cn

实验室已建立完善的跨学科研究平台,现常年提供研究岗位(博后、研究助理),并招收研究生(含联合培养),欢迎对神经科学感兴趣的生物学、医学、计算机专业等相关专业背景的候选人联系(feng.wang@siat.ac.cn)。


Biography

2018-              Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Associate Investigator

2013-2015      Institute of Mental Health Research, University of Ottawa, Postdoctoral Fellow 

2012-2018      Department of Anesthesiology, Xijing Hospital, Lecturer and Attending

2009-2012      Department of Anesthesiology, Xijing Hospital, Ph.D

2006-2009      Department of Anesthesiology, Xijing Hospital, M.Sc

2001-2006      Clinical Medicine, The 4rd Military Medical University, M.D


Selected publications

  1. ZhangYL#, Ke J#, Zhou Y, Liu X, Huang TW*, Wang F*. Sex-specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord. J Comp Neurol. 2022 May. Online ahead of print. 
  2. Liu X#, Huang H#, Zhang YL, Wang L, Wang F*. Sexual dimorphism of inputs to the lateral habenula in mice. Neurosci Bull. 2022 Mar. Online ahead of print.
  3. Liu X#, Huang HR#, Terrance S, Cao P, Wang LP, Wang F*. The superior colliculus: cell types, connectivity, and behavior. Neurosci Bull. 2022. Online ahead of print. 
  4. Tseng YT#, Zhao BH#, Chen SP#, Ye JL, Liu JJ, Liang LS, Ding H; Schaefke B, Yang Q, Wang LN, Wang F, Wang LP*. The subthalamic corticotropin-releasing hormone neurons mediate adaptive REM sleep responses to threat. Neuron. 2022 Online ahead of print.
  5. Yang C#, LiuJ#, Wang J, Yin A, Jiang Z, Ye S, Liu X, Zhang X, Wang F*, Xiong L* Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture. J Cereb Blood Flow Metab. 2021;41(9):2295-2310. 
  6. Liu X#, Li X#, Zhao G, Wang F*, Wang LP. Sexual dimorphic distribution of cannabinoid 1 receptor mRNA in adult C57BL/6J mice. J Comp Neuro. 2020;528(12):1986-1999.
  7. Tseng YT#, Zhao BH#, Liu JJ#, Ding H; Wang F, Wang LP*. Sleep deprivation and adrenalectomy lead to enhanced innate escape response to visual looming stimuli. Biochem Biophys Res Commun. 2020;527(3):737-743.      
  8. Wang F#, Han J#, Higashimori H#, Wang J#, Liu J, Tong L, Yang Y, Dong H, Zhang X*, Xiong L*. Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB1R after stroke in rodents. J Cereb Blood Flow Metab. 2019;39(6):1122-1137.
  9. Yin A#, Wang F*, Zhang Xia. Integrating Endocannabinoid Signaling in the Regulation of Anxiety and Depression. Acta Pharmacol Sin. 2019;40(3):336-341. 
  10. Liu X#, Chen C#, Liu Y#, Wang Z, Huang K, Wang F*and Wang LP*. Gentle handling attenuates innate defensive responses to visual threats. Front Behav Neurosci 2018;12:239.          
  11. Liu X#, Tian F, Wang S, Wang F*, Xiong L*. Astrocyte autophagy flux protects neurons against oxygen-glucose deprivation and ischemic/reperfusion injury. Rejuvenation Res. 2018 Oct;21(5):405-415.  
  12. Cai Y#, Peng Z#, Guo H, Wang F*, Zeng Y*. TREK-1 pathway mediates isoflurane-induced memory impairment in middle-aged mice. Neurobiol Learn Mem. 2017;16;145:199-204. 
  13. Wang F#, Li M#, Li X, Kinden R, Zhou H, Guo F, Wang Q*, Xiong L*. 2-Arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation.Rejuvenation Res.  2016;19:215-22.                                  
  14. Wang F#*, Liang W#, Lei C, Kinden R, Sang H, Xie Y, Huang Y, Qu Y, Xiong L*. Combination of HBO and memantine in focal cerebral ischemia: is there a synergistic effect? Mol Neurobiol. 2015;52:1458-66.                                  
  15. Wang F#, Zhong H#, Li X, Peng Y, Kinden R, Liang W, Li X, Shi M, Liu L, Wang Q*, Xiong L*. Electroacupuncture attenuates reference memory impairment associated with astrocytic NDRG2 suppression in APP/PS1 transgenic mice. Mol Neurobiol. 2014;50:305-13.
  16. Wang F#, Gao Z#, Li X, Li Y, Li X, Zhong H, Xu N, Cao F, Wang Q*, Xiong L*. NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats. Neurol Res. 2013;35:406-414.
  17. Wang Q#*, Wang F#, Li X#, Yang Q, Li X, Xu N, Huang Y, Zhang Q, Gou X, Chen S, Xiong L*. Electroacupuncture pretreatment attenuates cerebral ischemic injury through alpha7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats. J Neuroinflammation. 2012; 9:24.