ResearchExtensive evidences from genetic, neuropathological, biochemical, and biomarker studies suggest that amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD) pathogenesis. However, Aβ present in human brains is highly heterogeneous and the molecular characteristics of the key pathogenic Aβ forms are not clearly identified. In addition, the pathological, cellular and molecular mechanisms during AD progression are not well understood. The goal of our study is to dissect the role of Aβ in AD and ultimately develop therapeutic targets and biomarkers of AD.
Biography2019-present, Associate Professor, BCBDI, SIAT at CAS
2014-2019, Postdoctoral Fellow, Department of Neurology, Harvard Medical School/Brigham and Women’s Hospital
2009-2014, PhD, Microbiology, College of Life Sciences, Wuhan University
2005-2009, B.S., Biotechnology, College of Life Sciences, Wuhan University
Selected publications1.Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM: PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathologica (in press)
2.Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A: A vicious cycle of beta amyloid-dependent neuronal hyperactivation. Science 2019, 365:559-565.
3.Brinkmalm G#, Hong W#, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM: Identification of neurotoxic cross-linked amyloid-beta dimers in the Alzheimer's brain. Brain 2019, 142:1441-1457. (co-first author)
4.Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM: Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain. Acta Neuropathologica 2018, 136:19-40.
5.Zeng Z#, Zhang R#, Hong W#, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z: Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. Theranostics 2018, 8:199-211. (co-first author)
6.Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM: An in vitro paradigm to assess potential anti-Abeta antibodies for Alzheimer's disease. Nat Commun 2018, 9:2676.
7.Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ: Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo. J Neurosci 2018, 38:10595-10606.
8.Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM: Human Brain-Derived Abeta Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. J Neurosci 2017, 37:11947-11966.
9.Zeng Z, Han S, Hong W, Lang Y, Li F, Liu Y, Li Z, Wu Y, Li W, Zhang X, Cao Z: A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA. Mol Ther Nucleic Acids 2016, 5:e295.
10.Han SS, Li ZY, Zhu JY, Han K, Zeng ZY, Hong W, Li WX, Jia HZ, Liu Y, Zhuo RX, Zhang XZ: Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery. Small 2015, 11:2543-2554.
11.Hong W#, Lang Y#, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z: A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro. J Biol Chem 2015, 290:23254-23263. (co-first author)
12.Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z: Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. Antiviral Res 2014, 102:1-10.
13.Song Y, Gong K, Yan H, Hong W, Wang L, Wu Y, Li W, Cao Z: Sj7170, a unique dual-function peptide with a specific alpha-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom. J Biol Chem 2014, 289:11667-11680.
14.Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z: Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials 2013, 34:3511-3522.
15.Cao Z, Yu Y, Wu Y, Hao P, Di Z, He Y, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W: The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun 2013, 4:2602.
16.Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W, Cao Z: Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4alpha in vitro and in vivo. J Biol Chem 2012, 287:30181-30190.