Research

Despite extensive efforts over the years in the presynaptic field trying to understand the molecular mechanisms that underlie synaptic transmission, our knowledge of how phospholipids regulate synaptic transmission remains very limited. Specifically, it remains unclear how lipid recruits presynaptic proteins to executes its function?  How these protein-lipid interactions determine the efficiency of neurotransmitter release? Using genetic modified mice, two-photon imaging, electrophysiology in combination with optogenetic tools, which allows us to have spatiotemporal control of lipid composition at the presynaptic terminal, we aim to provide unequivocal insights into the role of lipids in synaptic transmission and plasticity.

Biography

Associate Principal investigator at SIAT CAS since 2020
2019-2020, Postdoctoral Fellow, Sickkids Hospital Toronto, Canada
2014-2017, Postdoctoral Fellow, Charite Berlin, Germany

2010-2013, PhD, Max Planck Institute for Biophysical Chemistry, Germany
2005-2007, Master in Biochemistry, Yang-Ming University, Taiwan

2001-2005, Bachelor in Life science, Cheng-Kung University, Taiwan

Selected publications

1.Chang S, Trimbuch T, Rosenmund C. Synaptotagmin-1 drives synchronous Ca²⁺ triggered fusion by C₂B domain-mediated slow and rapid vesicle membrane docking. Nat Neuroscience. 2018

2.Camacho-Perez M, Basu J, Trimbuch T, Chang S, Pulido-Lozano C, Chang S-S, Duluvova I, Abo Rady M, Rizo J and Rosenmund C. A central role of the Munc13 C₂A domain in vesicle docking, priming and vesicular release probability at central mammalian synapses. Nat Commum. 2017 

3.Vardar G, Chang S, Arancillo M, Wu YJ, Trimbuch T, Rosenmund C. Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons. J Neurosci. 2016 

4.Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H. Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.  J Neurosci. 2015 

5.Arnoldt H, Chang S, Jahnke S, Urmersbach B, Taschenberger H, Timme M. When less is more: non-monotonic spike sequence processing in neurons.  PLoS Comput Biol. 2015 

6.Taschenberger H, Lin K-H, Chang S. Presynaptic Ca²⁺ influx and its modulation at auditory calyceal terminals. Modulation of presynaptic calcium channels. Springer 2013 (Book chapter)