Research

Our group is aim to dissect the molecular regulatory mechanisms in development of Alzheimer's disease (AD). Particularly, different animal models such as familial AD (FAD, based on the gene mutation of APP, PSEN1 and PSEN2) and sporadic AD (SAD, based on ApoE4 manipulation) mice models will be used to investigate the underlying different molecular mechanisms between FAD and SAD. Moreover, four golden standards, including Mini-Mental State Examination (MMSE, behavior test), Magnetic resonance imaging (MRI) and positron emission tomography (Ab and Tau PET) imaging, Cerebrospinal fluid (CSF) analysis of AD biomarker, all of which are normally used in clinic diagnose will be applied in our research.

Biography

2023-present, Associate Investigator, BCBDI, SIAT-CAS

2016-2022, Assistant Investigator, BCBDI, SIAT-CAS

2014-2016, Postdoctoral Fellow, Shenzhen University

2008-2014, PhD, Biochemistry and Molecular Biology, University of Chinese Academy of Sciences

2004-2008, Bachelor in Biotechnology, Sichuan Agriculture University

Selected publications

(# Co-first author, * Corresponding author)

1. Yang, L., J. Shen, C. Liu, Z. Kuang, Y. Tang, Qian, Z., M. Guan, Y. Yang, Y. Zhan, N. Li and X. Li*. "Nicotine rebalances NAD(+) homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity." Nat Commun., 2023, 14(1): 900.
2. Yang, H#, Qian, Z.#, C. Liu, C. Tie, A. Cai, J. Wang, Y. Xing, J. Xia and X. Li*. "A versatile genetic-encoded reporter for magnetic resonance imaging." Heliyon, 2023, 9(3): e14054.
3. Qian, Z., C. Liu, H. Li, H. Yang, J. Wu, J. Liu, Y. Li, X. Chen, J. Xu and X. Li*. "Osteocalcin Alleviates Lipopolysaccharide-Induced Acute Inflammation via Activation of GPR37 in Macrophages." Biomedicines, 2022, 10(5).
4. Qian, Z., H. Li, H. Yang, Q. Yang, Z. Lu, L. Wang, Y. Chen and X. Li*. "Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain." Sci Adv., 2021, 7(43): eabi5811.
5. Qian, Z*#., H. Yang#, H. Li, C. Liu, L. Yang, Z. Qu and X. Li *. "The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe-/- Mice through Modulating Macrophage Functions." Biomedicines, 2021, 9(9).
6. Qian, Z.*, Li, H. Yang, J. Chen, X. Li and D. Gou*. "PDGFBB promotes proliferation and migration via regulating miR-1181/STAT3 axis in human pulmonary arterial smooth muscle cells." American Journal of Physiology-Lung Cellular and Molecular Physiology. 2018, 315(6): L965-L976.
7. Li, Y., L. Li, Qian, Z., B. Lin, J. Chen, Y. Luo, J. Qu, J. U. Raj and D. Gou. "Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells." Journal of the American Heart Association. 2018, 7(6).
8. Qian, Z*., Y. Li, J. Chen, X. Li and D. Gou*. "miR-4632 mediates PDGF-BB-induced proliferation and antiapoptosis of human pulmonary artery smooth muscle cells via targeting cJUN." American Journal of Physiology-Cell Physiology, 2017, 313(4): C380-C391.
9. Qian, Z., L. Zhang, J. Chen, Y. Li, K. Kang, J. Qu, Z. Wang, Y. Zhai, L. Li and D. Gou. "MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway." Oncotarget, 2016, 7(34): 54998-55011.
10. Chen, J., X. Cui, Qian, Z., Y. Li, K. Kang, J. Qu, L. Li and D. Gou. "Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells." Bmc Genomics, 2016,
11. Song, J., G. Ye, Qian, Z. and Q. Ye. "Virus-induced plasma membrane aquaporin PsPIP2; 1 silencing inhibits plant water transport of Pisum sativum." Botanical Studies, 2016, 57.
12. Qian, Z. #, Z. Wu#, L. Huang, H. Qiu, L. Wang, L. Li, L. Yao, K. Kang, J. Qu, Y. Wu, J. Luo, J. J. Liu, Y. Yang, W. Yang and D. Gou. "Mulberry fruit prevents LPS-induced NF-kappa B/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice." Scientific Reports, 2015, 5.
13. Qian, Z., JJ. Song, F. Chaumont and Q. Ye. "Differential responses of plasma membrane aquaporins in mediating water transport of cucumber seedlings under osmotic and salt stresses." Plant Cell and Environment, 2015, 38(3): 461-473.
14. Li, L., H. Wang, J. Gago, H. Cui, Qian, Z., N. Kodama, H. Ji, S. Tian, D. Shen, Y. Chen, F. Sun, Z. Xia, Q. Ye, W. Sun, J. Flexas and H. Dong. "Harpin Hpa1 Interacts with Aquaporin PIP1;4 to Promote the Substrate Transport and Photosynthesis in Arabidopsis." Scientific Reports, 2015, 5.
15. Qian, Z., H. Wang, T. Liu, Y. Jia, K. N. Prasad, H. Qu, X. Duan and Y. Jiang. "Changes in quality attributes of mandarin with- and without-leaf during refrigerated storage." Journal of Food Processing and Preservation, 2014, 38(1): 11-20.
16. Wang, H., Qian, Z., S. Ma, Y. Zhou, J. W. Patrick, X. Duan, Y. Jiang and H. Qu. "Energy status of ripening and postharvest senescent fruit of litchi (Litchi chinensis Sonn.)." Bmc Plant Biology, 2013, 13.
17. Qian, Z., T. Liu, H. Wang, H. Qu, C. Zhong, H. Huang and Y. Jiang. "Effects of Harvest Stage and Storage Temperature on Quality of 'Jin Yan' Kiwifruit(Actinidia chinensis * A.eriantha)." Journal of Tropical and Subtropical Botany, 2011, 19(2): 127-134.