ResearchNeurotransmitters in synaptic vesicles are the carrier of neural information. The neurotransmitter quantal release depends not only on the size of vesicles and the number of transmitters in a single vesicle, but also on the fusion mode and dynamic characteristics of vesicles fusion, which is critical in synaptic transmission mechanism, neural information coding and neurological diseases. Therefore, our current interests will focus on the following topics：
(1) the molecular and cellular mechanism of synaptic vesicle release,
(2) high- accuracy detection techniques and methods for synaptic vesicles signals in CNS in vivo.
Biography2019 – Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Accassociate Investigator.
2014 – 2019 Institute of Biophysics, CAS Accassociate Investigator.
2010 – 2014 Institute of Biophysics, CAS. Postdoctoral fellow.
2005 – 2010 Ph. D in Biomedical Engineering, Zhejiang University.
2001 – 2005 B.S. in Biomedical Engineering, University of Electronic Science and Technology of China.
Selected publications1. Zhao S, Liu L, Chen P#, Sun J, Shen X. Non-enzymatic fructose sensing by platinum decorated graphene oxide nanocomposite. Journal of Electroanalytical Chemistry. 2019, 845, 16-110. (# co-corresponding author)
2. Zhang S, Wang X, Wang X, Shen X, Sun J, Hu X, Chen P. Sr2+ has low efficiency in regulating spontanous release at the Calyx of Held synapses. Synapse. 2017, 71: e21983.
3. Zhang W, Chen P*#, Zhou L, et al. A biomimetic bioelectronic tongue: A switch for On- and Off- response of acid sensations. Biosens and Bioelectron. 2017, 92,523-528. (* co-first author and # co-corresponding author)
4．Chen P, Wu J, Zhao J, et al. PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium- dependent inactivation. Eur Biophys J. 2015, 44, 483-492
5. Dai J, Chen P, Tian H, Sun J. Spontaneous Vesicle Release Is Not Tightly Coupled to Voltage-Gated Calcium Channel- Mediated Ca2+ Influx and Is Triggered by a Ca2+ Sensor Other Than Synaptotagmin-2 at the Juvenile Mice Calyx of Held Synapses. J. Neurosci. 2015, 35(26), 9632-9637.
6．Chen P, Zhang W, Chen Pg, et al. A serotonin-sensitive sensor for investigation of taste cell-to-cell communication. Biosens and Bioelectron. 2011, 26, 3054-3058.
7．Chen P, Wang B, Cheng G, Wang P. Taste receptor cell-based biosensor for taste specific recognition based on temporal firing. Biosens and Bioelectron. 2009, 2515, 228-233. 8．Chen P, Liu X, Wang B, et al. A biomimetic taste receptor cell-based biosensor for electrophysiology recording and acidic sensation. Sensor Actuat B-Chem. 2009, 139 (2), 576-583.
9．Chen P, Zhang W, Zhou J, et al. Development of planar patch clamp technology and its application in the analysis of cellular electrophysiology. Prog Nat Sci. 2009, 19 (2), 153-160.
10．Chen P, Liu X, Zhang W, et al. Modeling and simulation of ion channels and action potentials in taste receptor cells. Sci. China Ser. C, 2009, 52(11):1036-1047.
11．Wu C, Chen P, Yu H, et al. A novel biomimetic olfactory-based biosensor for single olfactory sensory neuron monitoring. Biosens and Bioelectron. 2009, 24(15), 1498-1502.
12．Wu C, Chen P, Yuan Q, Wang P. Response enhancement of olfactory sensory neurons -based biosensors for odorant detection. J. Zhejiang Univ Sci B, 2009, 10 (4), 285-290.