ResearchMental disorders defined as disruption in neural circuits (NIMH) cause abnormal thoughts, emotions and behavior, such as schizophrenia, depression, addiction, post-traumatic stress disorder and others, which are recognized as one of the leading global health challenges. Fear is a basic and highly conserved emotion. Fear circuits and their important implication in understanding human fear and anxiety disorders is an emerging field in emotion and behavior neuroscience research. However, little is known about the cross talk of the neural circuits between the innate fear, learned fear and anxiety. Dissection of functional neural circuits for fear and anxiety will help us to understand the mechanisms of mental disorders at neural circuit level, also, will lead us to search the identification of biomarkers and novel candidate drug targets, as well as the development of novel mechanism-based cognitive or behavioral interventions for mental disorders. Research in this laboratory is to understand the neural circuitry basis of emotion and mental disorders, which is focused on: (1) determining the structure and function of brain specific neuronal subtypes control specific emotional behavior, including innate fear, learned fear and anxiety; (2) elucidating the modified neural circuits properties in mental disorders, such as schizophrenia and post-traumatic stress disorder.
Biography2014, National natural science fund for distinguished young scholars
2013, Young and middle-aged leading scientists, engineers and innovators
2008-present, Principal investigator at SIAT CAS
2005-2008, Postdoctoral research at the Department of Bioengineering at Stanford University with Prof. Dr. Karl Deisseroth;
2005, PhD degree in medical neuroscience from Charite-University Medicine, Berlin, Germany, with Prof. Dr. Helmut Kettenmann at the Department of Cellular Neurosciences, Max-Delbruck-Center for Molecular Medicine (MDC).
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