YE Keqiang

YE Keqiang

Ph.D, Principal investigator
Molecular mechanisms in neurodegenerative diseases, early diagnosis and drug development
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Research

Dr. Ye is the recipient of numerous professional honors, including the Distinguished Scientist Award from the Sontag Foundation (2003) and American Cancer Research Scholar (2004), and he is also one of the semi-finalists for Keck Foundation (2004). He has published approximately 220 papers with numerous papers in top journals including: Cell, Nature, Nature Medicine, Nature Cell Biology, Nature Neuroscience, Neuron, Mol. Cell, EMBO J, PNAS etc. His lab mainly focuses on neurotrophine-mediated neuronal survival singaling pathway and their role in neurodegenerative diseases. He identified numerous novel TrkA and TrkB agonists. These small molecules exhibit potent neurotrophic effect and display great therapeutic potentials for various neurological diseases including Alzheimer’s disease (AD). Most recently, he found that AEP acts as a novel delta-secretase that cleaves both APP and Tau and mediates AD pathogenesis. It is an innovative drug target for treating AD. His lab has identified the small molecular inhibitors that display promising therapeutic efficacy toward AD.


Biography

2021/09-present Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences - Head of the Department of Biology

09/2010-2021/08 Emory University School of Medicine, Department of Pathology and Laboratory Medicine  - Tenured Full Professor

09/2007-08/2010 Emory University School of Medicine, Department of Pathology and Laboratory Medicine  - Tenured Associate Professor

11/2001-08/2007 Emory University School of Medicine, Department of Pathology and Laboratory Medicine - Assistant Professor

1998-2001 Postdoctoral Fellow, Department of Neuroscience The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Supervisor: Solomon H. Snyder, MD


Selected publications

  1. Keqiang Ye, Yong Ke, Nagalakshmi Keshava, Judith A. Kapp, Rajeshwar R. Tekmal, John Petros and Harish C. Joshi (1998). Opium Alkaloid Noscapine is Anti-Tumor Agent That Arrests Metaphase and Induces Apoptosis in Dividing Cells. Proc. Natl. Acad. Sci. USA. 95, 1601-1606. (IF:11.205)
  2. Keqiang Ye, K. Joseph Hurt, Fredrick Y. Wu, Ming Fang, Hongbo R. Luo, Seth Blackshaw, Christopher D. Ferris and Solomon H. Snyder (2000). PIKE: a Nuclear GTPase That Enhances PI-3 Kinase Activity and is Regulated by Protein 4.1N. Cell. 103: 919-930. (IF:41.582)
  3. Keqiang Ye, Bahman Aghdassi, Hongbo R. Luo, Pann-Ghill Suh, and Solomon H. Snyder (2002). PLC-g1 is a Physiological Guanine Nucleotide exchange Factor for the Nuclear GTPase PIKE. Nature. 415, 541-544. (IF:49.962)
  4. Rong Rong, Honglian Huang, Eichiro Nagata, Daniel Kalman, Judith A. Kapp, Jiancheng Tu, Paul F. Worley, Solomon H. Snyder and Keqiang Ye (2003). PIKE-L/Homer Complex Couples mGluR I to PI 3-kinase, Preventing Neuronal Apoptosis. Nature Neuroscience 6, 1153-1161. (IF:24.884)
  5. Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Ye (2021). ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta Neuropathol. 142(1):139-158. (IF:17.088)
  6. Kecheng Lei, Yiyuan Xia, Xiao-Chuan Wang, Eun Hee Ahn, Lingjing Jin, Keqiang Ye (2020). C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation. Redox Biol. 34:101578. (IF:11.799)
  7. Yiyuan Xia, Zhi-Hao Wang, Jichun Zhang, Xia Liu, Shan Ping Yu, Karen X Ye, Jian-Zhi Wang, Keqiang Ye, Xiao-Chuan Wang (2020). C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Mol Psychiatry. doi: 10.1038/s41380-020-00956-4 (IF:15.992)
  8. Guiqin Chen, Seong Su Kang, Zhihao Wang, Eun Hee Ahn, Yiyuan Xia, Xia Liu, Ivette M Sandoval, Fredric P Manfredsson, Zhaohui Zhang, Keqiang Ye (2021). Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Sci Adv 7(16): eabe4499. (IF: 14.136)