The brain consists of myriad neurons that connect with one another through heterogeneous and plastic synaptic connections to form complex yet ordered circuits. Neuronal activity within and across these circuits shapes their connectivity and underlies perception, emotion, decision and learning in animals and human.
Towards understanding this complex system, Dr. Bi and colleagues are developing and applying cutting-edge light and electron microscopy techniques, as well as AI-based data processing methods, to explore brain circuits across multiple spatiotemporal scales. Through analyses of the acquired multi-modality data, the goal is to understand the structure, dynamics and function of brain circuits and the logic behind, and to inspire the next generation artificial intelligence.
Current research directions include:
(1) Synaptic architecture and mechanisms of plasticity;
(2) Brain mapping and circuit basis of learning and memory;
(3) New imaging and analysis techniques and their biomedical applications.
2020-, Principal Investigator, SIAT CAS
2007-, Professor, University of Science and Technology of China
2000-2008, Associate Professor (tenured), University of Pittsburgh School of Medicine
1996-2000, Postdoc, University of California at San Diego
1991-1996, PhD, University of California at Berkley
1990-1991, MS, University of New York
1985-1989, BS, Peking University
- Liu Y-T, Tao C-L, Zhang X, Qi L, Sun R, Lau P-M, Zhou H & Bi G-Q. (2020) Mesophasic organization of GABAA receptors in hippocampal inhibitory synapse. Nature Neuroscience (Accept).
- Xu C, Liu H-J, Qi L, Tao C-L, Wang Y-J, Shen Z, Tian C-L, Lau P-M & Bi G-Q. (2020)Structure and plasticity of silent synapses in developing hippocampal neurons visualized by super-resolution imaging. Cell Discovery 6, 1-11.
- Liu Y-T, Shivakoti S, Jia F, Tao C-L, Zhang B, Xu F, Lau P, Bi G-Q& Zhou ZH. (2020) Biphasic exocytosis of herpesvirus from hippocampal neurons and mechanistic implication to membrane fusion. Cell Discovery 6, 1-12.
- Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, Tian CL, Zhang P, Lau PM, Zhou ZH & Bi G-Q. (2018) Differentiation and characterization of excitatory and inhibitory synapses by cryo-electron tomography and correlative microscopy. J Neurosci, 38, 1493-1510.
- Wang H, Zhu Q, Ding L, Shen Y, Yang C-Y, Xu F, Shu C, Guo Y, Xiong Z, Shan Q, Jia F, Su P, Yang Q-R, Li B, He X, Chen X, Wu F, Zhou J-N, Xu F, Han H, Lau P-M &Bi G-Q. (2019) Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution. National Science Review 6, 982-992.
- Fu ZX, Tan X, Fang H, Lau PM, Wang X, Cheng H &Bi G-Q. (2017) Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity. Nat Commun 8, 31, doi:10.1038/s41467-017-00043-3.
- Shim SH, Xia C, Zhong G, Babcock HP, Vaughan JC, Huang B, Wang X, Xu C, Bi GQ & Zhuang X. (2012) Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes. Proc Natl Acad Sci USA 109, 13978-13983.
- Zhang JC, Lau PM &Bi G-Q. (2009) Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses. Proc Natl Acad Sci USA 106, 13028-13033.
- Wang HX, Gerkin RC, Nauen DW & Bi G-Q. (2005) Coactivation and timing-dependent integration of synaptic potentiation and depression. Nat Neurosci 8, 187-193.
- Lau PM & Bi G-Q. (2005) Synaptic mechanisms of persistent reverberatory activity in neuronal networks. Proc Natl Acad Sci USA 102, 10333-10338.
- Bi G-Q& Rubin J. (2005) Timing in synaptic plasticity: from detection to integration. Trends Neurosci 28, 222-228.
- Bi G-Q & Poo Mm. (2001) Synaptic modification by correlated activity: Hebb's postulate revisited. Annu Rev Neurosci 24, 139-166.
- van Rossum MC, Bi G-Q& Turrigiano GG. (2000) Stable hebbian learning from spike timing-dependent plasticity. J Neurosci 20, 8812-8821.
- Bi G-Q& Poo M-m. (1999) Distributed synaptic modification in neural networks induced by patterned stimulation. Nature 401, 792-796.
- Bi G-Q& Poo M-m. (1998) Synaptic modifications in cultured hippocampal neurons: Dependence on spike timing, synaptic strength, and postsynaptic cell type. J Neurosci 18, 10464-10472.
- Bi GQ, Alderton JM & Steinhardt RA. (1995) Calcium-regulated exocytosis is required for cell membrane resealing. J Cell Biol 131, 1747-1758.
- Steinhardt RA, Bi G-Q& Alderton JM. (1994) Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release. Science 263, 390-393.