LU Yi

LU Yi

PhD, Principal investigator
Director of the Shenzhen Engineering Lab for Brain Activity Mapping Technologies (BAMT)
Office Phone: 
0755-86132705
Email: 
Lab Website: 

Research

(1) Novel tools for neural recording and modulation, including flexible optogenetics, bio-sensors & actuators, electrode arrays and neural interfaces.

(2) Functional dissection and modulation of specific neural circuits involved in neuropsychological diseases (epilepsy & emotion disorders).

鲁艺,博士,研究员,所长助理。入选国家“优青”(交叉学部),广东省”杰青”,广东省特支计划(青拔),中国科学院青年创新促进会会员,深圳市高层次人才(地方级)。目前兼任中国神经科学学会神经科学研究技术分会秘书长,深圳市脑图谱解析关键技术与设备工程实验室主任。已在Nature Communications,Biomaterials等期刊上发表学术论文约30篇,担任Advanced Materials,Advanced Science等期刊审稿人。申请国家发明专利约100件,其中目前已授权约50件;获得2018年度广东省自然科学一等奖(2/15);主持各级科研项目共计15项。 

主要的研究方向包括:(1)神经调控和解析技术研发(柔性光遗传学和神经界面技术);(2)病理状态下的神经环路机制研究(癫痫、情绪障碍);(3)功能性生物材料和生物传感技术。实验室已建立完善的跨学科研究平台,现常年提供研究岗位(博后、研究助理),并招收研究生(含联合培养),欢迎对神经科学或生物材料学研究感兴趣的候选人联系(luyi@siat.ac.cn)。


Biography

2018-present, Principal Investigator and Professor at SIAT, CAS.

2014-present, Director of the Shenzhen Engineering Lab for BAMT.

2012-2018, Associate Professor at SIAT, CAS.

2010-2012, Assistant Professor at SIAT, CAS.

2005-2010, Ph.D. in Physical Chemistry, Wuhan University.

2001-2005, B.S. in Chemistry, Wuhan University.


Selected publications

  1. Zhang JJ#, Wang LL#, Xue Y#, Lei IM, Chen XM, Zhang P, Cai CC, Liang XY, Lu Y*, Liu J*, Engineering electrodes with robust conducting hydrogel coating for neural recording and modulation. Advanced Materials, in press.
  2. HouQH#, Wang LL#, Xiao Feng, Wang Le, Liu XY, Zhu LN, Lu Y*, Zheng WF*, Jiang XY*, Dual Targeting Nanoparticles for Epilepsy Therapy. Chemical Sciences, 2022;13:12913-20.
  3. Zhong C#, Wang LL#, Cao Y, Sun CY, Huang JY, Wang XF, Pan SW, He SY, Huang K, Lu ZH, Xu FQ, Lu Y*, Wang LP*, A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense. Cell Reports, 2022;41:111570.
  4. Cao Y#, Sun CY#, Huang JY, Sun P, Wang LL, HeSY, Liao JX, Lu ZH, Lu Y*, Zhong C*, Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice. Frontiers in Molecular Neuroscience, 2022;15:828891.
  5. SunCY#, Cao Y#, Huang JY, Huang K, Lu Y*, Zhong C*, Low-cost and easy-fabrication lightweight drivable electrode array for multiple-regions electrophysiological recording in free-moving mice. Journal of Neural Engineering, 2022;19:016003.
  6. Cao Y#, Pan SW#, Yan MY, Sun CY, Huang JY, Zhong C*, Wang LP*, Lu Y*, Flexible and stretchable polymer optical fibers for chronic brain and vagus nerve optogenetic stimulations in free-behaving animals. BMC Biology, 2021;19:252.
  7. Ye FM#, Cao Y#, Yan MY, Wang LL, Sun CY, Zhong C, Lu Y*, Low-cost Paper-based Conducting Polymer-hydrogel Flexible Bio-radar Sensor for Detecting Biological Objects. Macromolecular Materials & Engineering, 2021;202100447.
  8. Dong RH#, Wang LL#, Hang C, Chen Z, Liu XY, Zhong LN, Qi J, Huang YQ, Liu SQ*, Wang LP*, Lu Y*, Jiang XY*, Printed stretchable liquid metal electrode arrays for in vivo neural recording. Small, 2021;2006612.
  9. Chen HX#, Wang LL#, Lu Y*, Du XM*, Bioinspired microcone array-based living biointerfaces: enhancing anti-inflammatory effect and neuronal network formation. Microsystems & Nanoengineering, 2020;6:58.
  10. Wang LL#, Xie ZX#, Zhong C, Tang YQ, Ye FM, Wang LP*, Lu Y*. Self-spreadable Octopus-like Electrode Arrays for Long-term Neural Recordings. Acta Physico-Chimica Sinica. 2020;36:1909035.
  11. Ye FM#, Li M#, Ke DN, Wang LP, Lu Y*, Ultrafast Self-Healing and Injectable Conductive Hydrogel for Strain and Pressure Sensors. Advanced Materials Technologies, 2019;1900346.
  12. WangLL#, Zhong C#, Ke DN, Ye FM, Tu J, Wang LP*, Lu Y*, Ultra-soft and Highly Stretchable Hydrogel Optical Fibers for In Vivo Optogenetic Modulations. Advanced Optical Materials, 2018;6:1800427.
  13. Zhong C, Ke DN, Wang LL, Lu Y*, Wang LP*, Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface. Electrochemistry Communications, 2017;79:59-62.
  14. Lu Y#, Zhong C#,Wang LL, Wei PF, He W, Huang K, Zhang Y, Zhan Y, Feng GP, Wang LP*, Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nature Communications, 2016;7:10962.
  15. Zhong C, Zhang YY, He W, Wei PF, Lu Y*, Zhu Y, Liu L, Wang LP*. Multi-unit recording with iridium oxide modified stereotrodes in Drosophila melanogaster. Journal of Neuroscience Methods, 2014;222:218-29.
  16. Lu Y, Li YL, Pan JQ, Wei PF, Liu N, Wu BF, Cheng JB, Lu CY, Wang LP*. Poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)-poly(vinyl alcohol)/poly (acrylic acid) interpenetrating polymer networks for improving optrode-neural tissue interface in optogenetics. Biomaterials, 2012;33:378-94.
  17. Lu Y#, Li T#, Zhao XQ, Li M, Cao YL, Yang HX, Duan YY*. Electrodeposited polypyrrole/carbon nanotubes composite films electrodes for neural interfaces. Biomaterials, 2010;31:5169-81.
  18. Lu Y, Wang DF, Li T, Zhao XQ, Cao YL, Yang HX, Duan YY*. Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface. Biomaterials, 2009;30:4143-51.
  19. Lu Y, Wang TY, Cai ZX, Cao YL, Yang HX, Duan YY*. Anodically electrodeposited iridium oxide films microelectrodes for neural microstimulation and recording. Sensors & Actuators B:Chemical, 2009;137:334-9.
  20. Lu Y, Cai ZX, Cao YL, Yang HX, Duan YY*. Activated iridium oxide films fabricated by asymmetric pulses for electrical neural micro stimulation and recording. Electrochemistry Communications, 2008;10:778-82.