Research

(1) Novel tools for neural recording and modulation, including flexible optogenetics, bio-sensors & actuators, electrode arrays and neural interfaces.

(2) Functional dissection and modulation of specific neural circuits involved in neuropsychological diseases (epilepsy & emotion disorders).

鲁艺，博士，研究员，副所长。入选国家“优青”（交叉学部），广东省”杰青”，广东省特支计划（青拔），中国科学院青年创新促进会会员。目前同时担任中国神经科学学会学术工作委员会委员，神经科学研究技术分会副主任委员，深圳市脑图谱解析关键技术与设备工程实验室主任。已在Nature Communications，Advanced Materials，Cell Reports等期刊上发表学术论文30余篇，相关论文被Cell，Nature Materials，Chemical Reviews等期刊引用。申请国家发明专利超过100件，其中目前已授权约50件；获得2018年度广东省自然科学一等奖（第二完成人）；主持包括国家科技创新2030—“脑科学与类脑研究”重大项目在内的各级科研项目共计15项。

主要的研究方向包括：（1）神经调控和解析技术研发；（2）病理状态下的神经环路机制研究；（3）功能性生物材料和生物传感技术。实验室已建立完善的跨学科研究平台，现常年提供研究岗位（博后），并招收研究生（含联合培养），欢迎对神经科学或生物材料学研究感兴趣的候选人联系（luyi@siat.ac.cn）。

Biography

2018-present, Principal Investigator and Professor at SIAT, CAS.

2014-present, Director of the Shenzhen Engineering Lab for BAMT.

2012-2018, Associate Professor at SIAT, CAS.

2010-2012, Assistant Professor at SIAT, CAS.

2005-2010, Ph.D. in Physical Chemistry, Wuhan University.

2001-2005, B.S. in Chemistry, Wuhan University.

Selected publications

（^# Equal Contribution；* Corresponding Author）：

1. Dong RH^#, Wang LL^#, Li ZB^#, Jiao JC, Wu Y, Feng ZW, Wang XF, Chen ML, Cui C*, Lu Y*, Jiang XY*, Stretchable, self-rolled, microfluidic electronics enable conformable neural interfaces of brain and vagus neuromodulation. ACS Nano, 2024;18:1702-13.
2. Yan MY^#, Wang LL^#, Wu YY^#, Liao X, Zhong C, Wang LP, Lu Y*, Conducting polymer-hydrogel interpenetrating networks for improving the electrode-neural interface. ACS Applied Materials & Interfaces, 2023;15:41310-23.
3. Li HF^#, Han F^#, Wang LL^#, Huang LX, Samuel O, Zhao H, Xie RJ, Wang P, Tian Q, Li QS, Zhao Y, Yu M, Sun J, Yang RF, Zhou XM, Li F, Li GL, Lu Y*, Guo PZ*, Liu ZY*, A hybrid strategy-based ultra-narrow stretchable microelectrodes with cell-level resolution. Advanced Functional Materials, 2023;2300859.
4. Yan MY^#, Wang LL^#, Wu YY, Wang LP*, Lu Y*, Three-dimensional highly porous hydrogel scaffold for neural circuit dissection and modulation. Acta Biomaterialia, 2023;157:252-62.
5. Zhang JJ^#, Wang LL^#, Xue Y^#, Lei IM, Chen XM, Zhang P, Cai CC, Liang XY, Lu Y*, Liu J*, Engineering electrodes with robust conducting hydrogel coating for neural recording and modulation. Advanced Materials, 2023;2209324.
6. Hou QH^#, Wang LL^#, Xiao Feng, Wang Le, Liu XY, Zhu LN, Lu Y*, Zheng WF*, Jiang XY*, Dual Targeting Nanoparticles for Epilepsy Therapy. Chemical Science, 2022;13:12913-20.
7. Zhong C^#, Wang LL^#, Cao Y, Sun CY, Huang JY, Wang XF, Pan SW, He SY, Huang K, Lu ZH, Xu FQ, Lu Y*, Wang LP*, A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense. Cell Reports, 2022;41:111570.
8. Cao Y^#, Sun CY^#, Huang JY, Sun P, Wang LL, He SY, Liao JX, Lu ZH, Lu Y*, Zhong C*, Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice. Frontiers in Molecular Neuroscience, 2022;15:828891.
9. Sun CY^#, Cao Y^#, Huang JY, Huang K, Lu Y*, Zhong C*, Low-cost and easy-fabrication lightweight drivable electrode array for multiple-regions electrophysiological recording in free-moving mice. Journal of Neural Engineering, 2022;19:016003.
10. Cao Y^#, Pan SW^#, Yan MY, Sun CY, Huang JY, Zhong C*, Wang LP*, Lu Y*, Flexible and stretchable polymer optical fibers for chronic brain and vagus nerve optogenetic stimulations in free-behaving animals. BMC Biology, 2021;19:252.
11. Ye FM^#, Cao Y^#, Yan MY, Wang LL, Sun CY, Zhong C, Lu Y*, Low-cost Paper-based Conducting Polymer-hydrogel Flexible Bio-radar Sensor for Detecting Biological Objects. Macromolecular Materials & Engineering, 2021;202100447.
12. Dong RH^#, Wang LL^#, Hang C, Chen Z, Liu XY, Zhong LN, Qi J, Huang YQ, Liu SQ*, Wang LP*, Lu Y*, Jiang XY*, Printed stretchable liquid metal electrode arrays for in vivo neural recording. Small, 2021;2006612.
13. Chen HX^#, Wang LL^#, Lu Y*, Du XM*, Bioinspired microcone array-based living biointerfaces: enhancing anti-inflammatory effect and neuronal network formation. Microsystems & Nanoengineering, 2020;6:58.
14. Wang LL^#, Xie ZX^#, Zhong C, Tang YQ, Ye FM, Wang LP*, Lu Y*. Self-spreadable Octopus-like Electrode Arrays for Long-term Neural Recordings. Acta Physico-Chimica Sinica. 2020;36:1909035.
15. Ye FM^#, Li M^#, Ke DN, Wang LP, Lu Y*, Ultrafast Self-Healing and Injectable Conductive Hydrogel for Strain and Pressure Sensors. Advanced Materials Technologies, 2019;1900346.
16. Wang LL^#, Zhong C^#, Ke DN, Ye FM, Tu J, Wang LP*, Lu Y*, Ultra-soft and Highly Stretchable Hydrogel Optical Fibers for In Vivo Optogenetic Modulations. Advanced Optical Materials, 2018;6:1800427.
17. Zhong C, Ke DN, Wang LL, Lu Y^*, Wang LP*, Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface. Electrochemistry Communications, 2017;79:59-62.
18. Lu Y^#, Zhong C^#, Wang LL, Wei PF, He W, Huang K, Zhang Y, Zhan Y, Feng GP, Wang LP*, Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nature Communications, 2016;7:10962.
19. Zhong C, Zhang YY, He W, Wei PF, Lu Y^*, Zhu Y, Liu L, Wang LP*. Multi-unit recording with iridium oxide modified stereotrodes in Drosophila melanogaster. Journal of Neuroscience Methods, 2014;222:218-29.
20. Lu Y, Li YL, Pan JQ, Wei PF, Liu N, Wu BF, Cheng JB, Lu CY, Wang LP*. Poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)-poly(vinyl alcohol)/poly (acrylic acid) interpenetrating polymer networks for improving optrode-neural tissue interface in optogenetics. Biomaterials, 2012;33:378-94.
21. Lu Y^#, Li T^#, Zhao XQ, Li M, Cao YL, Yang HX, Duan YY*. Electrodeposited polypyrrole/carbon nanotubes composite films electrodes for neural interfaces. Biomaterials, 2010;31:5169-81.
22. Lu Y, Wang DF, Li T, Zhao XQ, Cao YL, Yang HX, Duan YY*. Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface. Biomaterials, 2009;30:4143-51.
23. Lu Y, Wang TY, Cai ZX, Cao YL, Yang HX, Duan YY*. Anodically electrodeposited iridium oxide films microelectrodes for neural microstimulation and recording. Sensors & Actuators B:Chemical, 2009;137:334-9.
24. Lu Y, Cai ZX, Cao YL, Yang HX, Duan YY*. Activated iridium oxide films fabricated by asymmetric pulses for electrical neural micro stimulation and recording. Electrochemistry Communications, 2008;10:778-82.