BAO Jin

BAO Jin

Ph.D, Principal investigator
Modulation of synaptic transmission and its dysfunction in mental diseases
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Research

突触是神经系统的结构和功能基础,突触传递的调控为网络计算提供多种元件,因而影响着神经网络的功能以及整体动物的行为输出。我们研究突触的周期性调控,包括昼夜节律,睡眠觉醒和情绪。我们同时与临床医生合作,探索疾病下的突触功能异常。

Synapse is one of the most important structures where neurons communicate with each other and neuronal circuit is formed. Synaptic plasticity is a general hardware implementation of learning and adaptation in the nervous system. Representation of the changing world and algorithms for adaptations are encoded in the diversity and complexity of synaptic plasticity. The ultimate goal of brain science is to understand the computation and its algorithms. Since we don't have a framework to start with on the computation, we started from analyzing the hardware. Synapse and its plasticity are the ubiquitous hardware in the nervous system. In addition, synapse and its plasticity underlie the majority of neuronal diseases, like developmental disorder, mental disorder and aging. Therefore, understanding synaptic plasticity and its modulation will contribute to both brain science and medicine. Our research group focuses on the modulatory factors that contribute to the rhythmic behaviors of synapses in physiological conditions like sleep-wake and circadian cycle, as well as in disease conditions.

Biography

2019-2020 Professor, School of Life Science, University of Science and Technology of China.
2014-2019 Associated Professor, School of Life Science, University of Science and Technology of China.
2011-2014 PostDoc Researcher, Marie Curie Fellow, The French National Centre for Scientific Research (CNRS).
2005-2010 PhD in Neuroscience, Max Planck Institute for Biophysical Chemistry, University of Goettingen, Germany.
2002-2005 Master student in Physics, Tsinghua University, Beijing.
1997-2002 Bachelor student in Biomedical Engineering, Zhejiang university, Hangzhou.

Selected publications

1.Bao J, Graupner M, Astorga G, Collin T, Jalil A, Indriati DW, Bradley J, Shigemoto R and Llano I (2020). Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo. eLife, 9, e56839

2.Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, Xue T*. Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell , 2019, 177(2): 243-255

3.Cheng J, Huang X, Liang Y, Xue T, Wang L*, Bao J* . Plasticity of Light-induced Concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus, Journal of Biological Rhythms , 2018, 33(1):65-75

4.Astorga G, Bao J , Franconville R, Jalil A, Bradley J, Llano I. An excitatory GABA loop operating in vivo. Frontiers in Cellular Neuroscience , 2015, 9, 275.

5.Huang CH, Bao J , and Sakaba T. Multivesicular Release Differentiates the Reliability of Synaptic Transmission between the Visual Cortex and the Somatosensory Cortex. Journal of Neuroscience , 2010, 30:11994 – 12004.

6. Bao J* , Reim K, Sakaba T*. Target-dependent feed-forward inhibition mediated by short-term synaptic plasticity in the cerebellum. Journal of Neuroscience , 2010, 30:8171-8179.

7.Bibitchkov D, Bao J , and Neher E. Information transmission by synapses with short-term synaptic plasticity. BMC Neuroscience , 2007, 8(Suppl 2), P90.