洪伟，副研究员，博士生导师，入选中国科学院百人计划，广东省珠江青年拔尖人才，深圳市高层次人才。2009年本科毕业于武汉大学生命科学与技术基地班，2014年获得武汉大学微生物学博士学位，2014至2019年在哈佛大学医学院从事博士后研究，2019年11月加入中国科学院深圳先进技术研究院。研究方向为：1）神经退行性疾病中的蛋白质异常聚集和传播机制；2）神经退行性疾病的诊断和干预策略。

神经退行性疾病

1. He Z^#, Zhang W^#, Chen P, Li S, Tao M, Yue F, Hong W*, Feng S*, Jing N*. Amyloid-beta oligomers drive amyloid deposit and cascaded tau pathology of Alzheimer's disease in aged brains of non-human primates. Journal of Genetics and Genomics 2025, 52(11):1367-1375
2. Chen P^#, Li J^#, Telezhkin V^#, Gu Y, Tao M, Guo L, Song S, Dong R, Luo X, Wang Y, Liu Q, Tian W, Meng W*, Hong W*, Song B*. Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis. Stem Cell Research & Therapy 2025, 16:406.
3. Song S^#, Liu Q^#, Huang X, Chen P, Tao M, Pei X, Wang H, Han Y, Chen J, Hong W*, Zhang Z*. Long-term electroacupuncture and repetitive transcranial magnetic stimulation differentially slow the progression of Alzheimer's disease in AppNL-G-F mice. Alzheimer's Research & Therapy 2025, 17:140
4. Song S^#, Liu Q^#, Chen R, Chen P, Tao M, Li S, Guo L, Zhu X, Liu Y, Liu L, Sasaguri H, Saito T, Saido TC, Walsh DM, Zhang Z*, Hong W*. Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity. Acta Neuropathologica Communications 2025, 13:112.
5. Liu Q, Song S, Liu L*, Hong W*. In vivo seeding of amyloid-β protein and implications in modeling Alzheimer’s disease pathology. Biomolecules 2025, 15: 571.
6. Li S^#, Liu Y^#, Luo X, Hong W. Systematic Evaluation of Extracellular Coating Matrix on the Differentiation of Human-Induced Pluripotent Stem Cells to Cortical Neurons. International Journal of Molecular Sciences 2025, 26:230.
7. Wang Z^#, Jin M^#, Hong W^#, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D*, Walsh DM*. Learnings about Abeta from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics. Acta Neuropathologica Communications 2023, 11:39.
8. Brinkmalm G^#, Hong W^#, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-beta dimers in the Alzheimer's brain. Brain 2019, 142:1441-1457.
9. Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science. 2019, 365:559-565.
10. Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain. Acta Neuropathologica 2018, 136:19-40.

累计发表SCI论文30余篇，其中第一作者或通讯作者（含并列）15篇，被引用3000余次，H指数21，申请发明专利10余项。主持国家自然科学基金面上和青年项目、中国科学院人才引进项目、广东省自然科学基金面上项目、深圳市基础研究重点项目和国际合作项目等9项，参与国家自然科学基金-国际(地区)合作与交流项目、广东省重点领域研发计划、深圳市高层次人才团队项目等。