Wei Hong is an Associate Investigator and PhD Supervisor, selected for the 100-Talent Program of the Chinese Academy of Sciences, and a recipient of the Guangdong Pearl River Young Top Talent and Shenzhen High‑Level Talent titles.
He received his B.Sc. from the National Base Class of Life Sciences and Technology, Wuhan University, in 2009, and his Ph.D. in Microbiology from Wuhan University in 2014.From 2014 to 2019, he conducted postdoctoral research at Harvard Medical School.In November 2019, he joined the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

His research interests include:
Abnormal protein aggregation and propagation mechanisms in neurodegenerative diseases;
Diagnostic and interventional strategies for neurodegenerative diseases.

1. He Z^#, Zhang W^#, Chen P, Li S, Tao M, Yue F, Hong W*, Feng S*, Jing N*. Amyloid-beta oligomers drive amyloid deposit and cascaded tau pathology of Alzheimer's disease in aged brains of non-human primates. Journal of Genetics and Genomics 2025, 52(11):1367-1375
2. Chen P^#, Li J^#, Telezhkin V^#, Gu Y, Tao M, Guo L, Song S, Dong R, Luo X, Wang Y, Liu Q, Tian W, Meng W*, Hong W*, Song B*. Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis. Stem Cell Research & Therapy 2025, 16:406.
3. Song S^#, Liu Q^#, Huang X, Chen P, Tao M, Pei X, Wang H, Han Y, Chen J, Hong W*, Zhang Z*. Long-term electroacupuncture and repetitive transcranial magnetic stimulation differentially slow the progression of Alzheimer's disease in AppNL-G-F mice. Alzheimer's Research & Therapy 2025, 17:140
4. Song S^#, Liu Q^#, Chen R, Chen P, Tao M, Li S, Guo L, Zhu X, Liu Y, Liu L, Sasaguri H, Saito T, Saido TC, Walsh DM, Zhang Z*, Hong W*. Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity. Acta Neuropathologica Communications 2025, 13:112.
5. Liu Q, Song S, Liu L*, Hong W*. In vivo seeding of amyloid-β protein and implications in modeling Alzheimer’s disease pathology. Biomolecules 2025, 15: 571.
6. Li S^#, Liu Y^#, Luo X, Hong W. Systematic Evaluation of Extracellular Coating Matrix on the Differentiation of Human-Induced Pluripotent Stem Cells to Cortical Neurons. International Journal of Molecular Sciences 2025, 26:230.
7. Wang Z^#, Jin M^#, Hong W^#, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D*, Walsh DM*. Learnings about Abeta from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics. Acta Neuropathologica Communications 2023, 11:39.
8. Brinkmalm G^#, Hong W^#, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-beta dimers in the Alzheimer's brain. Brain 2019, 142:1441-1457.
9. Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science. 2019, 365:559-565.
10. Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain. Acta Neuropathologica 2018, 136:19-40.

He has published more than 30 SCI papers in total, including 15 as first author or corresponding (co-corresponding) author, with over 3,000 citations and an H-index of 21.He has applied for more than 10 invention patents.
He has led 9 research projects, including the General Program and Young Scientists Fund of the National Natural Science Foundation of China, the Talent Recruitment Program of the Chinese Academy of Sciences, the General Program of the Natural Science Foundation of Guangdong Province, the Shenzhen Basic Research Key Program, and international cooperation projects.
He has also participated in the NSFC Joint Research Program (International/Regional Cooperation and Exchanges), the Guangdong Key Fields R&D Program, and the Shenzhen High-Level Talent Team Program.