Dr. Liu is currently an Associate Investigator at the Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences. He holds a Bachelor's degree in Biotechnology from Hunan University of Science and Technology and a Master's degree in Biochemistry and Molecular Biology from Shantou University (2011). Dr. Liu joined SIAT as a Research Assistant, where he advanced through the ranks, eventually becoming an Assistant Researcher. In 2016, he began his doctoral studies while continuing his research work, and he obtained his Ph.D. in January 2021 from the Shenzhen Institute of Advanced Technology, University of Chinese Academy of Sciences. Following the completion of his Ph.D., Dr. Liu was promoted to Associate Investigator.

Dr. Liu's research focuses on understanding the neural mechanisms underlying chronic stress-induced metabolic disorders. While acute stress may enhance performance, prolonged stress is closely linked to both emotional disorders and systemic metabolic dysfunctions. His work integrates interdisciplinary approaches to explore how the central nervous system regulates peripheral metabolic pathways under stress. Guided by the concepts of "central regulation of peripheral organs" and "inter-organ crosstalk," Dr. Liu's team is dedicated to uncovering the physiological mechanisms of stress-related diseases, with particular emphasis on central neural circuits, astrocyte function, and neuroendocrine regulation.

Chronic Stress-Induced Metabolic Disorders

1. Xiao YT, Yuan Q, Yang F*, Liu YH*. Chemogenetic modulation of parathyroid hormone secretion alleviates osteoporosis in ovariectomized rats. Biochemical and Biophysical Research Communications. 2025, 749, 151362
2. Li GY*, Liu YH*. Homogeneous and Significant Near-Field Enhancement in All-Dielectric Metasurfaces for Sensing Applications. Adv. Optical Mater. 2024, 2400425. DOI: 10.1002/ adom.202400425
3. Shao J#, Gao DS#, Liu YH#, Chen SP, Liu N, Zhang L, Zhou XY, Xiao Q, Wang LP, Hu HL, Yang F*. Cav3.1-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure. Mol Psychiatry. 2022 Jun;27(6):2901-2913.
4. Liu YH#, Zhang L#, Hu N#, Shao J, Yang DZ, Ruan CS, Huang SS, Wang LP, Lu WW, Zhang XZ*, Yang F*. An Optogenetic Approach for Regulating Human Parathyroid Hormone Secretion. Nat Commun. 2022 Feb 9;13(1):771. doi: 10.1038/s41467-022-28472-9.
5. Shao J#, Liu YH#, Gao DS, Tu J, Yang F*. Neural Burst Firing and its Roles in Mental and Neurological Disorders. Front. Cell. Neurosci. 2021. 15:741292. doi: 10.3389/ fncel.2021. 741292.
6. Liu YH#, Shao J#, Gao DS, Zhang L, Yang F*. Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice. Neural Plast. 2021 Jul 8;2021:7806370. doi: 10.1155/2021/7806370.
7. Yang F#*, Liu YH#, Chen SP, Dai ZQ, Yang DZ, Gao DS, Shao J, Wang YY, Wang T, Zhang ZJ, Zhang L, Lu WW, Li YH*, Wang LP*. A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress-induced bone loss. J Clin Invest. 2020 Dec 1;130(12):6539-6554
8. Yang F#, Liu YH#, Tu J#, Wan J, Zhang J, Wu BF, Chen SP, Zhou JW, Mu YL, Wang LP*, Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF, Nat Commun., 2014.12.17, 5(5627)

Dr. Liu's research centers on the neural mechanisms that drive metabolic disorders induced by chronic stress. He has successfully led multiple research projects funded by the National Natural Science Foundation of China (NSFC) and the Shenzhen Medical Research Fund. His work has contributed significantly to understanding the complex interactions between stress and metabolism, with a focus on how the brain influences peripheral metabolic pathways and the development of stress-related diseases.