Dr. Shan's research focuses on the neural mechanisms of human/non-human primate brain functions and the pathology of brain disorders. She employs pattern recognition and machine learning methods, combined with EEG/SEEG/spike/MRI data analysis techniques, to investigate the neural basis of cognitive functions and brain functional abnormalities associated with diseases. Her work also extends to developing closed-loop brain–computer interfaces as novel tools for therapeutic neural modulation. 

cognitive mechanisms in human/non-human primates and the pathology of brain disorders.

1. Shan L#, Yuan L#, Zhang B#, Ma J, Xu X, Gu F, et al. Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions. Neuroscience Bulletin 39.12 (2023) (Cover, JCR-Q1, IF=5.9)

2. Shan L#*, Huang H#, Zhang Z, Wang Y, Gu F, Lu M, et al. Mapping the emergence of visual consciousness in the human brain via brain-wide intracranial electrophysiology. The Innovation 3.3 (2022) (JCR-Q1, IF=33.2)

3. Zhang Z#, Shan L#, Wang Y#, Li W, Jiang M, Liang F, et al. Primate preoptic neurons drive hypothermia and cold defense. The Innovation 4.1 (2023) (JCR-Q1, IF=33.2)

4. Liu Y, Shan L, Liu T, Li J, Chen Y, Sun C, et al. Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin. Neuron 111.9 (2023) (JCR-Q1, IF=14.7)

5. Yefei Chen#, Zexuan Hong#, Jingyi Wang, Kunlin Liu, Jing Liu, Jianbang Lin, Shijing Feng, Tianhui Zhang, Liang Shan, Taian Liu, Pinyue Guo, Yunping Lin, Tian Li, Qian Chen, Xiaodan Jiang, Anan Li,Xiang Li, Yuantao Li, Jonathan J. Wilde, Jin Bao*, Ji Dai* and Zhonghua Lu*. 2023. Circuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease model. Cell 186.24 (2023) (JCR-Q1, IF=45.5)

Dr. Shan research findings have been published as corresponding or first author in journals including The Innovation, Neuroscience Bulletin, and Schizophrenia Research. She has also contributed to research published in journals including Neuron and Cell. She has led projects including the National Natural Science Foundation of China (NSFC) Young Scientists Program, the Guangdong Provincial Natural Science Foundation General Program and Young Scientists Program, and the Shenzhen Municipal Natural Science Foundation General Program.