个人简介
Liang Gao, Associate Investigator, Master's Supervisor, Shenzhen Municipal Talent Liang Gao received his doctoral degree from the University of Heidelberg, Germany, in 2014.From 2015 to 2017, he conducted postdoctoral research at the German Cancer Research Center (DKFZ).
研究领域
His current research focuses on the neural regulatory mechanisms of immune homeostasis.Taking immune-related diseases of the central nervous system as the entry point, he investigates the neural regulatory mechanisms underlying immune homeostasis imbalance during disease progression.
代表论著
1. Kuo Lu, Keng Po Lai, Tobias Stoeger, Shuqin Ji, Ziyi Lin, Xiao Lin, Ting Fung Chan, James Kar-Hei Fang, Michael Lo, Liang Gao, Chen Qiu, Shanze Chen, Guobing Chen , Lei Li, Lingwei Wang. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. J. Hazard. Mater. 2021;416:126069.
2. Gülcüler Balta, Gülce S., Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka and Ana Martin-Villalba. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Reports 29 (8): 2295-2306.e6. doi:10.1016/j.celrep.2019.10.054.
3. Dehler, Sascha, Wilson Pak-Kin Lou, Liang Gao, Maxim Skabkin, Sabrina Dällenbach, Andreas Neumann, and Ana Martin-Villalba. 2018. “An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury.” Frontiers in Molecular Neuroscience 11 (December): 1–12. doi:10.3389/fnmol.2018.00443.
4. Liang Gao, Gülce Sila Gülcüler, Lieke Golbach, Helena Block, Alexander Zarbock, and Ana Martin-Villalba*. 2016. “Endothelial Cell-Derived CD95 Ligand Serves as a Chemokine in Induction of Neutrophil Slow Rolling and Adhesion.” eLife 5 (OCTOBER2016): 1–20. doi:10.7554/eLife.18542.
5. Liang Gao#, David Brenner#, Enric Llorens-Bobadilla, Gonzalo Saiz-Castro, Tobias Frank, Peter Wieghofer, Oliver Hill, Meinolf Thiemann, Saoussen Karray, Marco Prinz, Jochen H. Weishaupt, and Ana Martin-Villalba*. 2015. “Infiltration of Circulating Myeloid Cells through CD95L Contributes to Neurodegeneration in Mice.” The Journal of Experimental Medicine 212 (4): 469–80. doi:10.1084/jem.20132423.
科研\学术成果
His representative achievements include more than 10 SCI publications and 2 authorized patents. He reported for the first time internationally that brain infiltration of myeloid cells exacerbates neurodegeneration in mouse models.He also uncovered a novel molecular and cellular mechanism that induces chemotaxis of myeloid cells, providing a new perspective for the treatment of brain diseases from the angle of immune regulation.