Bo Feng graduated with a bachelor's degree in Pharmacy from Shanghai Jiao Tong University and obtained her Ph.D. in Pharmacology from Zhejiang University. She has also conducted postdoctoral research at the University of California, San Diego. She has published papers as a corresponding or co-author in journals including Brain Behavior and Immunity, Science Advances, Nature Communications, Cell Reports, PNAS, and the British Journal of Pharmacology.

The focus of the laboratory is to understand the molecular mechanisms of neurodegenerative diseases (e.g. Alzheimer's disease, Parkinson's disease) from the perspectives of synapse loss and brain-body interaction, and on developing related drug targets.

1. R Song, C Liu, M Peng, Z Qian, M Wei, F Yu, M Yao, X Li*, B Feng*. CX3CL1-CX3CR1 pathway mediates hyperthermia-induced microglial processes retraction. Brain, Behavior, and Immunity 2025 Jul:127:205-216.
2. Z Shen, B Feng, WL Lim, T Woo, Y Liu, S Vicenzi, J Wang, BK Kwon, Y Zou*. Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury. Proceedings of the National Academy of Sciences 2025 122 (15), e2417400122.
3. AE Freitas, B Feng, T Woo, S Galli, C Baker, Y Ban, J Truong, A Beyeler, and Y Zou*.Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress. Nature Communications, 2024 15 (1), 4945
4. B Feng, A Freitas, L Gorodetski, R Tian, YR Lee, J Wang, A Grewal, and Y Zou*. Planar cell polarity signaling regulates adult synapse maintenance and is a direct target of amyloid-β associated synapse degeneration.Science Advances 2021; 7: eabh2307.
5. Y Wan#, B Feng#, Y You#, J Yu, C Xu, H Dai, B Trapp, P Shi, Z Chen*, W Hu*. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures.Cell Reports 2020 33 (5), 108346. 
6. Y Tang#, B Feng#, Y Wang, H Sun, Y You, J Yu, B Chen, C Xu, Y Ruan, S Cui, G Hu, T Hou, and Z Chen* Structure‐based discovery of caspase‐1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility.British Journal of Pharmacology 2020 177:3519–3534.

1. Discovered that planar cell polarity proteins signaling is targeted in Alzheimer’s disease. Identified monoclonal antibodies targeting the PCP signaling pathway, demonstrating potential for therapeutic value.

2. Revealed that the complement signaling pathway ADAM10-CX3CL1-CX3CR1 is involved in regulating microglial morphology and migration.

3. Identified the role of pathological protein deposits in peripheral organs in the onset of neurodegenerative diseases and aim to identify new targets for drug intervention from this perspective.