Dr. Jing's research centers on the molecular mechanisms of neuron-glia interactions, with works towards understanding how glial cells support brain function. She identified Dmp1-positive astrocytes as a specialized cerebrovascular-associated subtype and demonstrated that glycosylation of DMP1 is critical for blood-brain barrier integrity by regulating the sealing of blood-brain barrier. Building on this, she further deciphered neuronal control over oligodendrocyte development, revealing that disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through the mTORC1-DLK1 axis, with establishment the essential role of the imprinted gene Dlk1 in myelination. Currently, she is extending this work by modeling Amyotrophic Lateral Sclerosis and dissecting neuron-oligodendrocyte crosstalk in health and disease.

Molecular mechanisms of neuron-glia interaction in neurological disorders.

1. Huang, H. #, Jing, B.#*, Zhu, F., Chen, H., Ren, G., Xia, S., Wang, Luo, Yang, Z., Jiang, W., Cui, Y., Chen, M., Paul F. Worley*, and Bo Xiao*. (2023). Disruption of Neuronal RHEB Signaling Impairs Oligodendrocyte Differentiation and Myelination through mTORC1-DLK1 Axis. Cell Reports, 42(7), 112801
2. Jing, B., Zhang, C., Liu, X., Zhou, L., Liu, J., Yao, Y., Yu, J., Weng Y., Pan. M., Liu J., Wang, Z.*, Sun, Y.*, Yi Eve Sun*. (2018). Glycosylation of Dentin Matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity. Protein and cell, 9(3):298-309.
3. Yian Wang#, Wenxia Gao#, Xueyan Yang, Zirui Liu, Hisham Al-Ward, Orion R Fan, Yiming Shao, Liqiang Zhou, Bo Jing, Qianxiang Wu, Wenmin Zhu*, Wei Chen*, Yi Eve Sun*. (2025). Spatial cell atlas of lateral septum reveals changes underlying anxiety and fear learning deficits in immunocompromised mice. Int J Biol Sci, 2025;21(14):6389-6410.
4. Feiyan Zhu, Haijiao Huang, Yuting Shu, Guoru Ren, Bo Jing, Honglin Tan, Wanxiang Jiang, Yiyuan Cui, Paul Worley, Bo Xiao*, and Mina Chen*. (2025). Repeated Ablations of Mature Tmem10+ Oligodendrocytes Recapitulates Key Pathological Features of Multiple Sclerosis with Prolonged Demyelination, Cell Death & Disease, On line.
5. Yang, W., Pang, D., Chen, M., Du, C., Jia, L., Wang, L., He, Y., Jiang, W., Luo, L., Yu, Z., Mao, M., Yuan, Q., Tang, P., Xia, X., Cui, Y., Jing, B., Platero, A., Liu, Y., Wei, Y., . . . Xiao, B. (2021). Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation. Dev Cell, 56(6), 811-825 e816.
6. Zhang, C., Zhou, L., Wang, Z., Gao, W., Chen, W., Zhang, H., Jing, B., Zhu, X., Chen, L., Zheng, C., Shi, K., Wu, L., Cheng, L., Zhang, K., & Sun, Y. E. (2021). Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell Death Dis, 12(4), 357.

Dr. Jing is a Principal Investigator supported by the National Natural Science Foundation of China and serves as a key technical member of a National Key R&D Program of China. As an active member of the Chinese Society for Neuroscience, she also contributes to translational research infrastructure, participating in the development of the Shenzhen Nervous System Disease Concept Validation Center—a major municipal initiative aimed at advancing cell therapy platform.