Yuewen Chen, Associate Investigator, Principal Investigator / PhD Supervisor. Yuewen Chen received his B.Sc. from Lanzhou University in 2005, his M.Sc. from Peking Union Medical College in 2009, and his Ph.D. from Jinan University in 2012 (joint Ph.D. program with The Hong Kong University of Science and Technology).

His research focuses on the molecular and cellular mechanisms of cerebral cortex development, as well as diagnostic and therapeutic strategies for developmental brain disorders.

1.Jinying Xu, Jianhui Man, Yingying Fan, Yuewen Chen*, Yu Chen*. (2026) Axin1 stabilizes S-opsin and maintains cone photoreceptor survival by inhibiting GSK3β activity. Cell Death & Discovery, 12(1):109.
2.Qiang Fu, Rui Qiu, Tongtong Yao, Liming Liu, Yaobo Li, Xiaodong Li, Wen Qi*, Yuewen Chen*, Yong Cheng*. (2025) Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model. Translational Psychiatry 15(1):143.
3.Xiaopu Zhou#, Han Cao#, Yuanbing Jiang, Yuewen Chen, Huan Zhong, Wing Yu Fu, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Ying Mok, Timothy C.Y. Kwok, Vincent C.T. Mok, Fanny C.F. Ip, Alzheimer’s Disease Neuroimaging Initiative, Akinori Miyashita, Norikazu Hara, Takeshi Ikeuchi, John Hardy, Yu Chen, Amy K.Y. Fu, Nancy Y. Ip*. (2025) Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer’s disease. Alzheimer's & Dementia 21(1):e14214.
4.Lei Chen, Yang Du, Yang Hu, Xue-Song Li, Yuewen Chen*, Yong Cheng*. (2024) Whole-exome sequencing of individuals from an isolated population under extreme conditions implicates rare risk variants of schizophrenia. Translational Psychiatry 14(1):267.
5.Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma, Jinying Xu, Yingying Fan, Yuewen Chen*, Yu Chen*. (2024) Coronin 2B deficiency induces nucleolar stress and neuronal Apoptosis. Cell Death and Disease 15(6):457.
6.Qiang Fu, Rui Qiu, Lei Chen, Yuewen Chen*, Wen Qi*, Yong Cheng. (2023) Music prevents stress-induced depression and anxiety-like behavior in mice. Translational Psychiatry 13(1):317.
7.Yuewen Chen#, Zhenyan Xu#, Jing Chen#, Yue Qiu, Lin Yuan, Peng Liu, Jing Duan, Li Chen*, Yu Chen*. (2023) Coronin 2B Regulates neuronal migration via Rac1-dependent multipolar–bipolar transition. Journal of Neuroscience 43 (2): 211-220.
8.Yangyang Duan#, Tao Ye#, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K Y Fu, Viviana Gradinaru, Nancy Y Ip*. (2021) Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice. Nature Biomedical Engineering 6(2):168-180.
9.Yuewen Chen#, Jinying Xu#, Yulin Zhang, Shuangshuang Ma, Wanying Yi, Saijuan Liu, Xiaojun Yu, Jiali Wang, Yu Chen*. (2020) Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. FEBS Letters 594(18):2975-2987. 
10.Yuewen Chen, Fanny C.F. Ip, Lei Shi, Zhe Zhang, Huibin Tang, Yu Pong Ng, Wen-Cai Ye, Amy K.Y. Fu, Nancy Y. Ip. (2014) Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton, Journal of Neuroscience 34(7):2413–21.

He has published nearly 40 SCI papers in total. He serves as Principal Investigator for the Young Scientists Fund of the National Natural Science Foundation of China and the General Program of the Natural Science Foundation of Guangdong Province.As a core member, he has participated in multiple national, provincial and ministerial research programs, including the National Key R&D Program of China, the NSFC–Hong Kong RGC Joint Research Scheme, the Guangdong Key Fields R&D Program, and the Guangdong–Shenzhen Joint Fund Team Project.