Fuqiang Xu is a recipient of the National Science Fund for Distinguished Young Scholars and an awardee of the Chinese Academy of Sciences “Excellent Hundred Talents Program”.He earned his Ph.D. in Chemistry in 1994 and Ph.D. in Physiology in 1998, both from the University of Kentucky, USA. He has successively served as:
Associate Research Scientist at the Magnetic Resonance Research Center, Yale University
Director of the Translational Research Center for Neurological Disorders, Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Professor at the Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences
Director of the Guangdong Provincial Key Laboratory for Quality Control of Viral Vectors in Cell and Gene Therapy (Guangdong Medical Products Administration)
Director of the NMPA Key Laboratory for Research and Evaluation of Viral Vectors in Cell and Gene Therapy Medicinal Products (National Medical Products Administration)
Director of the Shenzhen Key Laboratory of Biomedical Viral Vectors
Director of the Guangdong Provincial Key Laboratory of Biological (Virus) Technology in Universities

Here is the rigorous, academic English translation, formatted for official profile / research paper use: Fuqiang Xu's research primarily integrates the fundamental principles and cutting-edge advances from molecular biochemistry, cell and neurobiology, bioengineering, and biomedical imaging to develop viral tools for biomedicine. These include viral vectors for the structural and functional dissection of neural circuits, viral vectors for gene therapy, and oncolytic viruses for tumor lysis.

1.Li M#, Liu Z, Wu Y, Zheng N, Liu X, Cai A, Zheng D, Zhu J, Wu J, Xu L, Li X, Zhu LQ, Manyande A, Xu F*, Wang J. In vivo imaging of astrocytes in the whole brain with engineered AAVs and diffusion-weighted magnetic resonance imaging. Mol Psychiatry. 2024 Mar;29(3):545-552. doi: 10.1038/s41380-022-01580-0. Epub 2022 Apr 28. PMID: 35484244.

2.Zhang J#, Xu Q, Zhang Y, Foda MF, Cai K, Liu Q, Jia F, Wang H, Xu F*, Han H, Liang H. Natural bioactive lysosomes extracted from multiple cells for tumor therapy. Biomaterials. 2024 Jan;304:122430. doi: 10.1016/j.biomaterials.2023.122430. Epub 2023 Dec 11. PMID: 38100907.

3.Zhu H, Tao Y, Wang S, Zhu X, Lin K, Zheng N, Chen LM, Xu F*, Wu R. fMRI, LFP, and anatomical evidence for hierarchical nociceptive routing pathway between somatosensory and insular cortices. Neuroimage. 2024 Apr 1;289:120549. doi: 10.1016/j.neuroimage.2024.120549. Epub 2024 Feb 20. PMID: 38382864.

4.Zheng N#, Gui Z#, Liu X, Wu Y, Wang H, Cai A, Wu J, Li X, Kaewborisuth C, Zhang Z, Wang Q, Manyande A, Xu F*, Wang J. Investigations of brain-wide functional and structural networks of dopaminergic and CamKIIα-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies. J Transl Med. 2023 Aug 14;21(1):543. doi: 10.1186/s12967-023-04362-6. PMID: 37580725; PMCID: PMC10424380.

5.Han Z#, Luo N#, Ma W, Liu X, Cai Y, Kou J, Wang J, Li L, Peng S, Xu Z, Zhang W, Qiu Y, Wu Y, Ye C, Lin K, Xu F*. AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction. Nat Commun. 2023 Jun 26;14(1):3792. doi: 10.1038/s41467-023-39554-7. PMID: 37365155; PMCID: PMC10293207.

By integrating fundamental principles and cutting-edge advances in molecular and cell biology, genetics, virology, neurobiology, biology, imaging, chemistry, and physics, he focuses on the development of novel technologies and methods to reveal the structure and function of neural circuits using neurotropic viruses as probes.
His team has independently developed the most comprehensive and internationally leading library of neurotropic viral tools, covering more than 100 variants including herpes simplex virus type 1 (HSV-1), pseudorabies virus (PRV), rabies virus (RV), vesicular stomatitis virus (VSV), adeno-associated virus (AAV), canine adeno-associated virus (CAV), and Semliki Forest virus (SFV). A national platform for neural circuit tracing has been established, providing support to more than 100 outstanding laboratories worldwide.
These achievements have been highlighted as key accomplishments in the excellent conclusion of the NSFC Major Program on Emotional Memory Circuits and the excellent mid-term evaluation of the CAS Strategic Priority Research Program (Class B) on Brain Connectomics.
He has published more than 80 SCI papers in high-impact journals including Science, Nature Neuroscience (2), Neuron (5), and Nature Communications (4), with more than 20 domestic and international patents filed or granted.
In the past five years, he has led as principal investigator multiple major research projects, including the Key Project and the Integration Project of the Major Research Plan, the International (Regional) Cooperation and Exchange Program, and the General Program of the National Natural Science Foundation of China; the Strategic Priority Research Program (Class B) and Key Breakthrough Program of the Chinese Academy of Sciences; and a subproject of the National Basic Research Program of China (973 Program).