Dr. Yang is a talent in national technological innovation Program and a high-level overseas talent in Shenzhen. His group focuses on the neural mechanisms underlying central nervous system perception and regulation of bone metabolism. His team has made several key discoveries, including: Elucidating the neural pathways through which chronic stress drives bone loss (Journal of Clinical Investigation 2020, Molecular Psychiatry 2022); Revealing how the brain modulates parathyroid hormone secretion to counteract bone loss (Nature Communications 2022, Neuron 2023); and Uncovering mechanisms of bone sensation mediated by the brain and peripheral nerves (Neuron 2024, Bone Research 2025). His work has been published in leading international journals such as Neuron, Journal of Clinical Investigation, and Nature Communications. Dr. Yang has directed multiple major research programs, including projects funded by the National Natural Science Foundation of China (Major and General Programs), the National Key R&D Program of the Ministry of Science and Technology. Among his honors, Dr. Yang received the 2019 Second Prize in Basic Orthopedic Research from the Chinese Medical Association, the 2018 First Prize in Natural Science of Guangdong Province, and the 2017 First Prize in Natural Science of Shenzhen. He currently serves as the Vice Chair and Secretary General of the Autonomic Nervous System Committee of the Chinese Association for Physiological Sciences.

Neural circuits regulating bone metabolism and stem cell homeostasis.

1． Huang SS#, Gao DS#, Li ZX#, He HC#, Yu X, You XH, Wu DW, Zeng JC, Shi XJ, Hu QS, Nie Y, Zhang Z, Luo ZY, Wang D, Zhao ZH, Li LL, Wang GL, Wang LP, Zhou ZK*, Chen D*, Yang F*；Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans; Bone Research; 13, 4 (2025). https://doi.org/10.1038/s41413-024-00382-0
2． Zhou XY, Xiao Q, Liu YH, Chen S, Xu XR, Zhang ZG, Hong YC, Shao J, Chen YW, Chen Y, Wang LP*, Yang F*, Tu J*. Astrocyte-mediated regulation of BLAWFS1 neurons alleviates risk-assessment deficits in DISC1-N mice. Neuron. 2024 Apr 16:S0896-6273(24)00235-6.
3． Zhang L#, Liu N#, Shao J, Gao DS, Liu YH, Zhao YZ, Han CL, Chen D, Wang LP, Lu WW*, Yang F*. Bidirectional control of parathyroid hormone and bone mass by subfornical organ. Neuron. 2023 Apr 10;S0896-6273(23)00226-X.
4． Liu YH#, Zhang L#, Hu N#, Shao J, Yang DZ, Ruan CS, Huang SS, Wang LP, Lu WW, Zhang XZ*, Yang F*. An optogenetic approach for regulating human parathyroid hormone secretion. Nature Communications. 2022 Feb 9;13(1):771. doi: 10.1038/s41467-022-28472-9.
5． Shao J#, Gao DS#, Liu YH#, Chen SP, Liu N, Zhang L, Zhou XY, Xiao Q, Wang LP, Hu HL, Yang F*. Cav3.1-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure. Molecular Psychiatry. 2022Jun; 27(6):2901-2913. doi: 10.1038/s41380-022-01513-x

Dr. Fan Yang's group primarily investigates the mapping and modulation of central neural circuits, as well as the mechanisms of brain-bone interactions. In recent years, corresponding-author papers from the lab have been published in leading international journals, including Bone Research (2025), Neuron (2024, 2023), Nature Communications (2022), Molecular Psychiatry (2022), and The Journal of Clinical Investigation (2020). Currently, Dr. Yang leads several major research programs, including a Major Program from the National Natural Science Foundation of China, a National Key R&D Program from the Ministry of Science and Technology, a Key Research Program of Frontier Sciences from the Chinese Academy of Sciences, and a Shenzhen Medical Research Special Fund project.