陈宇，研究员，博士生导师，深圳市级人才。2007年获香港科技大学博士学位，2015年加入深圳先进院脑认知与脑疾病研究所，现任副所长、深港脑科学创新研究院副院长、神经发育与退行性脑疾病研究中心主任。主要致力于研究神经突触发育和可塑性机制、神经退行性病变的分子机制和生物标志物等，获中国神经科学学会2021年度“神经科学重大进展”（境内完成单位第一负责人）。

神经发育和可塑性的调控机制；神经系统疾病的致病机理和生物标志物

1.Jinying Xu^#, Jianhui Man, Yingying Fan, Yuewen Chen*, Yu Chen* (2026) Axin1 stabilizes S-opsin and maintains cone photoreceptor survival by inhibiting GSK3β activity. Cell Death & Discovery, accepted.
2.Xikang Feng^#, Yinhu Li^#, Jieyi Zheng^#, Xuhua Chen^#, Shuo Yang, Yu Chen*, Shuai Cheng Li*. (2025) MicrobialScope: an integrated genomic resource with rich annotations across bacteria, archaea, fungi, and viruses. Nucleic Acids Research, 54(D1), D842–D851.
3.Xueqi Qu, Li Lin, Yinhu Li, Yuewen Chen, Yu Chen*. (2025) N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer's disease. Genes and immunity, 26(5):438-448.
4.Jiaming Li, ……, Yu chen*, …… , Guang-Hui Liu*. (2025) The X-Age Project to construct a Chinese aging clock. Nature Aging, 5(9):1669-1685.
5.Yujie Yang, Yinhu Li, Yu Chen*. (2025) Changes in transcriptional regulation in the temporal lobe in patients with Alzheimer's disease. Journal of Alzheimer's Disease, 104(4):1075-1091.
6.Chunyu Lyu^#, Lin Yuan^#, Yang Yang, Dongsheng Zhang, Wei Hu, Keli Zhao, Yuzhen Ding, Wei Chen, Kang Xiao*, Yu Chen*, Wei Liu*. (2025) Ligand preference of EphB2 receptor is selectively regulated by N-glycosylation. iScience, 28(5):112386.
7.Yinhu Li^#, Xikang Feng^#, Xuhua Chen#, Shuo Yang, Zicheng Zhao, Yu Chen*, Shuaicheng Li*.  (2025) PlasmidScope: A comprehensive plasmid database with rich annotations and online analytical tools. Nucleic Acids Research, 53(D1):D179-D188.
8.Yinhu Li^#, Guangze Pan^#, Shuai Wang#, Zhengtu Li, Ru Yang, Yiqi Jiang, Yu Chen*, Shuai Cheng Li*, Bairong Shen*. (2024) Comprehensive human respiratory genome catalogue underlies the high resolution and precision of the respiratory microbiome. Briefings in Bioinformatics, 26(1): bbae620.
9.Zhigang Zhang^#, Shuai Chen^#, Shirui Jun^#, Xirong Xu, Yuchuan Hong, Xifei Yang, Liangyu Zou, You-Qiang Song*, Yu Chen*, Jie Tu*. (2025) MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis. Autophagy, 21(2):424-446.
10.RanYi^#, ShuaiChen^#, Mingfeng Guan, Chunyan Liao, Yao Zhu, Jacque Pak Kan Ip, TaoYe*, Yu Chen*. (2024) A single-cell transcriptomic dataset of pluripotent stem cell-derived astrocytes via NFIB/SOX9 overexpression. Scientific Data, 11:987.
11.Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma, Jinying Xu, Yingying Fan, Yuewen Chen, Yu Chen*. (2024) Coronin 2B deficiency induces nucleolar stress and neuronal Apoptosis. Cell Death and Disease, 15(6):457.
12.Mengqi Li^#, Mingfeng Guan^#, Jianbang Lin^#, Kaichuan Zhu^#, Jiayi Zhu, Ming Guo, Yinhu Li, Yefei Chen, Yijing Chen, Ying Zou, Daiqiang Wu, Junxin Xu, Wanying Yi, Yingying Fan, Shuangshuang Ma, Yuewen Chen, Jun Xu, Lixin Yang, Ji Dai, Tao Ye*, Zhonghua Lu*, Yu Chen*. (2024) Early blood immune molecular alterations in cynomolgus monkeys with a PSEN1 mutation causing familial Alzheimer’s disease. Alzheimer's & Dementia, 20(8), 5492–5510.
13.Yijing Chen^#, Yinhu Li^#, Yingying Fan, Shuai Chen, Li Chen, Yuewen Chen, Yu Chen*. (2024) Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice. Gut Microbes, 16(1):2302310.
14.Yinhu Li^#, Yijing Chen#, Yingying Fan, Yuewen Chen, Yu Chen*. (2023) Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice. Gut Microbes, 15(1):2172672.
15.Yuewen Chen^#, Zhenyan Xu^#, Jing Chen#, Yue Qiu, Lin Yuan, Peng Liu, Jing Duan, Li Chen*, Yu Chen*. (2022) Coronin 2B Regulates neuronal migration via Rac1-dependent multipolar–bipolar transition. Journal of Neuroscience, 43 (2): 211-220.

在Alzheimer‘s & Dementia、Gut Microbes、Nature Neuroscience、PNAS、Journal of Cell Biology、Pharmacology & Therapeutics等著名学术期刊上发表论文50余篇，申请多项国际专利。作为项目负责人主持“国家重点研发计划”战略性国际科技创新合作重点专项、国自然国际(地区)合作与交流项目（NSFC-RGC）、科技部规划司战略研究项目、广东省区域联合基金粤港澳研究团队项目、国家自然科学基金面上项目、中科院对外合作重点项目、深圳市基础研究学科布局等项目。