YANG Fan

YANG Fan

PhD, Principal investigator
Office Phone: 
86-755-26703551

Introduction

Central nervous system plays an important role in maintaining the homeostasis of human body and regulating the physiological functions of peripheral organs. However up to now, the mechanism of central neural regulation of bone metabolism remain unclear. Our research interests are mainly focused on how different neural circuits and neuron subtypes exert influences on bone metabolism in disease models. Recently we have identified a GABAergic neural circuit in the ventromedial hypothalamus mediating chronic stress-induced bone loss, which support the crucial role of central neural circuits in maintaining the homeostasis of bone metabolism. Currently, we are using cutting-edge technology including optogenetics, chemogenetics and neural tracing to dissect the underlying mechanism of crosstalk between the brain and the bone.