IntroducationIn healthy humans, physiological parameters, such as body temperature and blood pressure, are tightly controlled by the central nervous system (CNS) and maintained in a balanced condition termed homeostasis. It is believed that the metabolic homeostasis is achieved by feedback loops consisting of sensors, homeostats and effectors. In recent years, growing evidence suggests that the brain is the key hub which orchestrates multiple homeostatic processes. Specific neurons function as homeostats within the brain: they compute signals arising from peripheral sensors and send efferent controls to peripheral effectors. However, the locations of homeostats, their molecular identity, and their connections to the sensors and the effectors remains largely unknown. With the help of modern genetic, anatomical and neural circuit mapping tools, it is possible to dissect the pathways underling central control over homeostatic processes. My research will be focused on following areas: (1) genetic dissection of CNS cell types and circuits controlling homeostatic processes; (2) profiling of CNS cells during homeostasis and homeostatic breakdown; (3) methods to restore homeostasis in diseases; (4) intrinsic interactions between homeostatic processes.