Introduction

Neurotransmitters in synaptic vesicles are the carrier of neural information. The neurotransmitter quantal release depends not only on the size of vesicles and the number of transmitters in a single vesicle, but also on the fusion mode and dynamic characteristics of vesicles fusion, which is critical in synaptic transmission mechanism, neural information coding and neurological diseases. Therefore, our current interests will focus on the following topics：
(1) the molecular and cellular mechanism of synaptic vesicle release,
(2) high- accuracy detection techniques and methods for synaptic vesicles signals in CNS in vivo.