LI Lei

LI Lei

PHD,Associate Investigators
LI Lei focuses on the impact of stress and negative emotions on sexual behavior and other related social behaviors.
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Lei LI focuses on the neural mechanism of stress and its impact on reproduction, using state of art techniques like optogenetics, pharmogenetics, single-cell sequencing. Li has published 12 articles in peer-reviewed journals including Current Biology and Biology of Reproduction. She is the principal investigator of two NSFC grants (Youth and General). Postdocs and candidate Master or Ph.D. students who are interested in this field can contact Li at


As a freshwoman in Nanjing University, Li received full scholarship to pursuit undergraduate study in Hong Kong in 2001. She graduated from the University of Hong Kong with her PhD degree in Molecular Medicine in 2010. Li joined SIAT in 2011 and right now is an Associate Professor at BCBDI, SIAT CAS. She worked as short-term Visiting Scientist in McGovern Institute for Brain Research at MIT and Affiliate of BROAD Institute during 2017-2018.

Selected publications

1. Li, L.# Feng X#, Zhou Z#, Zhang H, Shi Q, Lei Z, Shen P, Yang Q, Zhao B, Chen S, Li L, Zhang Y, Wen P, Lu Z, Li X, Xu F and Wang LP. “Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection” Current Biology, (2018) /j.cub.2018.02.005 (#co-first author)

2. Li L.* and Wong LP*. Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit. Journal of Experimental Neuroscience (2018) 12:1-3. (* co-corresponding author)

3. Li, L#., C. Huang#, X. Zhang, J. Wang, P. Ma, Y. Liu, T. Xiao, B. A. Zabel and J. V. Zhang Chemerin-Derived Peptide C-20 Suppressed Gonadal Steroidogenesis. American Journal of Reproductive Immunology 2014 71(3): 265-277. (#co-first author)

4. Li, L#, P. Ma#, C. Huang, Y. Liu, Y. Zhang, C. Gao, T. Xiao, P. G. Ren, B. A. Zabel and J. V. Zhang Expression of chemerin and its receptors in rat testes and its action on testosterone secretion. Journal of Endocrinology 2014;220(2): 155-163. (#co-first author)

5. Li, L#., P. Ma#, Y. Liu, C. Huang, W. S. O, F. Tang and J. V. Zhang (2013). Intermedin attenuates LPS-induced inflammation in the rat testis. PLoS One 2013; 8(6): e65278. (#co-first author)

6. Li, L., W. S. O and F. Tang Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1. Reproductive Biology and Endocrinology 2011;9: 111.

7. Li, L., F. Tang and W. S. O. Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation. Reproductive Biology and Endocrinology 2010;8: 130.

8. Li, L., F. Tang and W. S. O. Preimplantation antagonism of adrenomedullin action compromises fetoplacental development and reduces litter size. Theriogenology 2012; 77(9): 1846-1853

9. Li, L. and C. K. Wong. Effects of dexamethasone and dibutyryl cAMP on stanniocalcin-1 mRNA expression in rat primary Sertoli and Leydig cells. Molecular and Cellular Endocrinology 2008;283(1-2): 96-103.

10. Zhou CR#, Zhou Z#, Han YS, Lei ZG, Li L, Montardy Q, Liu XM, Xu FQ, Wang LP. Activation of parvalbumin interneurons in anterior cingulate cortex impairs observational fear. Science Bulletin 2018, 63:771-778.

11. Zhang, J. V., Li, L, Q. Huang and P. G. Ren. Obestatin receptor in energy homeostasis and obesity pathogenesis. Progress in molecular biology and translational science114: 89-107.

12. Li, Y. Y., Li, L, I. S. Hwang, F. Tang and W. S. O. Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary. Biology of Reproduction 2008 79(2): 200-208.