ResearchMy current research is focused on the technological developments of multiphoton microscopy and optical coherence tomography to quantitatively and microscopically assess microvascular blood flow, oxygen delivery and consumption, and neurovascular coupling in rodent brains. My long-term research goals include:
1)developing novel optical tools and methods.
2)applying them to study brain function and physiology in both healthy and diseased conditions.
Biography2020-Present, Associate Professor, Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China.
2015-2019, Postdoc, Massachusetts General Hospital, Harvard Medical School, USA.
2014-2015, Postdoc, École Polytechnique, University of Montreal, Canada.
2009-2014, Ph.D. in Biomedical Engineering, École Polytechnique, University of Montreal, Canada.
2006-2008, M.S. in Optical Engineering, Tianjin University, China.
2002-2006, B.E. in Electronic Information Science and Technology, Liaocheng University, China.
Selected publications1.Baoqiang Li(#), Xuecong Lu(#), Mohammad Moeini, Sava Sakadžić, Eric Thorin, and Frederic Lesage(*), “Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation,” PLoS One, 2019.
2.Baoqiang Li(#), Tatiana V. Esipova(#), Ikbal Sencan, Kıvılcım Kılıç, Buyin Fu, Michele Desjardins, Mohammad Moeini, Sreekanth Kura, Mohammad A. Yaseen, Frederic Lesage, Leif Østergaard, Anna Devor, David A. Boas, Sergei A. Vinogradov, and Sava Sakadžić(*), “More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction,” eLife, 2019.
3.Baoqiang Li(*), Ryo Ohtomo, Martin Thunemann, Stephen R Adams, Jing Yang, Buyin Fu, Mohammad A Yaseen, Chongzhao Ran, Jonathan R. Polimeni, David A. Boas, Anna Devor, Eng H. Lo, Ken Arai, and Sava Sakadžić, “Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion,” J. Cereb. Blood Flow Metab., 2019.
4.Baoqiang Li(*), Hui Wang, Buyin Fu, Ruopeng Wang, Sava Sakadžić, and David Boas, “Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography,” J. Biomed. Opt., 2017.
5.Baoqiang Li(*), Jongwhan Lee, David Boas, and Frederic Lesage, “Contribution of low- and high-flux capillaries to slow hemodynamic fluctuations in the cerebral cortex of mice,” J. Cereb. Blood Flow Metab., 2016.
6.Baoqiang Li, Romain Berti, Maxime Abran, and Frederic Lesage(*), “Ultrasound guided fluorescence molecular tomography with improved quantification by an attenuation compensated born-normalization and in vivo preclinical study of cancer,” Rev. Sci. Instrum., 2014.
7.Baoqiang Li, Foued Maafi, Romain Berti, Philippe Pouliot, Eric Rhéaume, Jean-Claude Tardif, and Frederic Lesage(*), "Hybrid FMT-MRI applied to in vivo atherosclerosis imaging," Biomed. Opt. Express, 2014.
8.Baoqiang Li, Maxime Abran, Carl Matteau-Pelletier, Léonie Rouleau, Tina Lam, Rishi Sharma, Eric Rhéaume, Ashok Kakkar, Jean-Claude Tardif, and Frédéric Lesage(*), "Low-cost three-dimensional imaging system combining fluorescence and ultrasound," J. Biomed. Opt., 2011.