LI Baoqiang

LI Baoqiang

PhD, Associate Investigator
Research interests: biomedical optics, neurophotonics, multiphoton microscopy, cerebral blood flow and oxygen metabolism, and neurovascular coupling
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My current research is focused on the technological developments of multiphoton microscopy to assess neuronal physiology, cerebral blood flow and oxygen metabolism, and neurovascular coupling in preclinical models. My long-term research goals include 1) developing advanced optical imaging tools and methods, and 2) applying them to study brain physiology and function.


2020-Present, Associate Investigator, Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China.
2015-2019, Postdoc, Massachusetts General Hospital, Harvard Medical School. 2014, Ph.D. in Biomedical Engineering, École Polytechnique, University of Montreal.

Selected publications

1. Baoqiang Li(#), Xuecong Lu(#), Mohammad Moeini, Sava Sakadžić, Eric Thorin, and Frederic Lesage(*), “Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation,” PLoS One, 2019.

2. Baoqiang Li(#), Tatiana V. Esipova(#), Ikbal Sencan, Kıvılcım Kılıç, Buyin Fu, Michele Desjardins, Mohammad Moeini, Sreekanth Kura, Mohammad A. Yaseen, Frederic Lesage, Leif Østergaard, Anna Devor, David A. Boas, Sergei A. Vinogradov, and Sava Sakadžić(*), “More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction,” eLife, 2019.

3. Baoqiang Li(*), Ryo Ohtomo, Martin Thunemann, Stephen R Adams, Jing Yang, Buyin Fu, Mohammad A Yaseen, Chongzhao Ran, Jonathan R. Polimeni, David A. Boas, Anna Devor, Eng H. Lo, Ken Arai, and Sava Sakadžić, “Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion,” J. Cereb. Blood Flow Metab., 2019.

4. Baoqiang Li(*), Hui Wang, Buyin Fu, Ruopeng Wang, Sava Sakadžić, and David Boas, “Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography,” J. Biomed. Opt., 2017.

5. Baoqiang Li(*), Jongwhan Lee, David Boas, and Frederic Lesage, “Contribution of low- and high-flux capillaries to slow hemodynamic fluctuations in the cerebral cortex of mice,” J. Cereb. Blood Flow Metab., 2016.