ResearchVirus is a special smart and powerful microbe, which has harmful and useful aspects, just likes a double-edged sword, for human and animals. The useful aspect has been applied in the fields of basic research and medicine by deleting harmful aspect, e.g. Pseudorabies virus and Rabies virus have been used to mapping neural circuit, Adeno-associated virus has been used for curing genetic disease, Lentivirus has been used for preparing modified immune cells (CAR-T), Herpes simplex virus has been modified to destroy cancer, etc. However, some problems are still needed to be resolved, such as high toxicity, low efficiency, complex production protocol, high-cost, etc.
Therefore, I focus on these points for developing :
i)Novel and high-efficient virus-based tools: retrograde/anterograde tracers ( e.g. PRV/RV/SINV), helpers (e.g.LV/ReV), sparse labeling tool, gilal cells-targeted, single plasmid delivery, condition-dependent life cycle, etc.
ii)Convenient and cost-effective methods for large-scale production of viral vectors (e.g. LV, RV, etc).
iii)Exploring the mechanism of virus-host interaction.
Biography2019-present, Associate investigator at Shenzhen institute of advanced technology, Chinese Academy of Science
2012-2019, Associate investigator at Wuhan institute of physics and mathematics, Chinese Academy of Science
2012, Wuhan Youth Chenguang Program of Science and Technology
2010-2012, Assistant investigator at Wuhan institute of virology, Chinese Academy of Science
2010, PhD degree in microbiology from Wuhan institute of virology, Chinese Academy of Science
Selected publications1.Jia F*, Lv P, Miao H, Shi X, Mei H, Li L, Xu X,Tao S, Xu F*. Optimization of the Fluorescent Protein Expression Level Based on Pseudorabies Virus Bartha Strain. Frontiers in Neuroanatomy, 2019.
2.Jia F*#, Zhu X#, Lv P, Hu L, Liu Q, Jin S, Xu F*. Rapid and Sparse Labeling of Neurons Based on the Mutant Virus-Like Particle of Semliki Forest Virus. Neuroscience Bulletin, 2019.
3.Xu F#, Lin Z#, Wang X, Jia F, Ma K, Wang N, Lin L, Xu F, Shen Y*. Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells. Nature neuroscience. 2019.
4.Guo B#, Chen J#, Chen Q#, Ren K, Feng D, Mao H, Yao H, Yang J, Liu H, Liu Y, Jia F, Qi C, Lynn-Jones T, Hu H, Fu Z, Feng G*, Wang W*, Wu S*. Anterior Cingulate Cortex Dysfunction Underlies Social Deficits in Shank3 Mutant Mice. Nature neuroscience. 2019.
5.Jia F*, Zhu X, Xu F*. A single adaptive point mutation in Japanese encephalitis virus capsid is sufficient to render the virus as a stable vector for gene delivery. Virology, 2016.