DAI Ji

DAI Ji

PhD, Associate Professor
Neural Regulation of Vision, Attention and Emotion in Nonhuman Primates
Office Phone: 
86-755-86146121

Research

We are interested in understanding the neural circuits of visual perception, attention, and emotion in the nonhuman primates, and how we can regulate these basic functions through manipulating the activities of specific neurons or pathways.
To this end, we use several novel neuromodulation techniques including optogenetics, chemogenetics, in combination with electrophysiological and brain imaging techniques, to uncover how visual information is encoded in the brain, how attention modulates perception, how emotion interacts with cognition, and how these functions can be manipulated in the behaving monkeys. Eventually, we hope our findings can help to pave the way for extensively translational studies and clinical application in the near future.

Keywords

Monkey, Optogenetics, Chemogenetics, Electrophysiology, iEEG, Machine learning, Brain-machine interface

                                                                                                                                                                                                               

Open Positions
Postdoc and Research Assistant positions are open for application. We also welcome part time students from all over the world. Please send your CV and application to Dr. Dai for more information.


Biography

2017.10- present, Associate Professor (PI) at SIAT CAS
2014.9-2017.9, Associate Professor at Institute of Psychology, CAS
2010.9-2015.2, Postdoctoral Research Associate at Brown University
2003.9-2010.1, Institute of Biophysics, CAS, PhD
1999-9-2003.6, Nanjing University, B.S


Selected publications

  1. Yefei Chen#, Jingyi Wang#, Jing Liu#, Jianbang Lin, Yunping Lin, Jinyao Nie, Qi Yue, Chunshan Deng, Xiaofei Qi, Yuantao Li, Ji Dai*, Zhonghua Lu*. “A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys”, Neuroscience Bulletin, 2024, 40(1):90-102.
  2. Zhiting Zhang, Ji Dai*. “Fully implantable wireless brain-computer interface for humans: Advancing toward the future”, The Innovation, 2024, 5:100595.
  3. Gaojia Zhang#, Ling Li#, Yan Kong#,*, Dandan Xu, Yu Bao, Zhiting Zhang, Zhixiang Liao, Jiao Jiao, Dandan Fan, Xiaojing Long, Ji Dai, Chunming Xie, Zhiqiang Meng*, Zhijun Zhang*. “Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder”, Genes & Disease, 2024, 11(2):1009-1021.
  4. Yefei Chen#, Zexuan Hong#, Jingyi Wang, Kunlin Liu, Jing Liu, Jianbang Lin, Shijing Feng, Tianhui Zhang, Liang Shan, Taian Liu, Pinyue Guo, Yunping Lin, Tian Li, Qian Chen, Xiaodan Jiang, Anan Li, Xiang Li, Yuantao Li, Jonathan Wilde, Jin Bao*, Ji Dai*, and Zhonghua Lu*. “Circuit-Specific Gene Therapy Reverses Core Symptoms in a Primate Parkinson’s Disease Model”, Cell, 2023, 186 (24): 5394-5410.e18.
  5. Jingyi Wang#, Jianbang Lin#, Yefei Chen#, Jing Liu, Qiongping Zheng, Mao Deng, Ruiqi Wang, Yujing Zhang, Shijing Feng, Zhenyan Xu, Weiyi Ye, Yu Hu, Jiamei Duan, Yunping Lin, Ji Dai, Yu Chen, Yuantao Li, Tao Luo, Qian Chen*, and Zhonghua Lu*. “An Ultra-Compact Promoter Drives Widespread Neuronal Expression in Mouse and Monkey Brains”, Cell Reports, 2023, 42:113348.
  6. Panke Yu#, Zhiting Zhang#, Yuyin Wang, Ji Dai*. “Protocol for MRI-guided virus injection in macaque deep brain regions”, STAR Protocols, 2023, 4:102768.
  7. Chunshan Deng, Xiaojian Li, Ji Dai*. “Challenges for translating implantable brain-computer interface to medical device”, The Innovation Medicine, 2023, 1:100040.
  8. Xinhe Liu, Lu Gan, Zhiting Zhang, Panke Yu, Ji Dai*. “Probing the Processing of Facial Expression via Time Perception and Eye Tracking in Monkeys”, Zoological Research, 2023, 44(5):882-893.
  9. Ji Dai*, Xin Cao, Yong Han, Tianbin Song, Yuming Guo, Jie Qiao. “The Innovation Medicine: An international journal of medical science”, The Innovation Medicine, 2023, 1:100001.
  10. Ji Dai*, “Launching from Earth”, The Innovation, 2023, 4:100430.
  11. Liang Shan#, Liu Yuan#, Bo Zhang#, Jian Ma, Xiao Xu, Fei Gu, Yi Jiang*, Ji Dai*. “Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions”, Neuroscience Bulletin, 2023, 39(12):1749−1761. (Cover article)
  12. Zhiting Zhang#, Liang Shan#, Yuyin Wang#, Wenfang Li, Minqing Jiang, Feng Liang, Shijing Feng, Zhonghua Lu, Hong Wang*, Ji Dai*. “Primate Preoptic Neurons Drive Hypothermia and Cold Defense”. The Innovation, 2023, 4:100358.
  13. Liang Shan#,*, Hui Huang#, Zhiting Zhang, Yuyin Wang, Fei Gu, Mingwei Lu, Wen Zhou, Yi Jiang*, Ji Dai*, “Mapping the Emergence of Visual Consciousness in the Human Brain via Brain-wide Intracranial Electrophysiology”, The Innovation, 2022, 3:100243.
  14. Ying Zhang#*, Dheeraj Roy#*, Yi Zhu, Yefei Chen, Tomomi Aida, Yuanyuan Hou, Chenjie Shen, Nicholas Lea, Margaret Schroeder, Keith Skaggs, Heather Sullivan, Kyle Fischer, Edward Callaway, Ian Wickersham, Ji Dai, Xiao-Ming Li, Zhonghua Lu, Guoping Feng*. “Targeting thalamic circuits rescues motor and mood deficits in PD mice”, Nature, 2022, 607: 321-329.
  15. Lu Gan, Jinglong Wu, Ji Dai*, Shintaro Funahashi*. “The Mechanism for Allocating Limited Working Memory Resources in Multitasking”, Neuroscience Bulletin, 2022, 38(7):829-833.
  16. Jiani Chen, Liang Shan, Ji Dai*. “Distinct Recovery Process of Consciousness and Cognition after Anesthesia”, Neuroscience Bulletin, 2022, 38(1): 110-112.
  17. Yongjun Xu, Qi Wang, Zhulin An, et al., “Artificial Intelligence: A Powerful Paradigm for Scientific Research”. The Innovation, 2021, 2:100179.
  18. Ji Dai*. “Gaining a Better Understanding of Nonhuman Primate Research”, Science Bulletin, 2021, 66(15):1499-1501.
  19. Yuxuan Yao, Ji Dai*. “Naturally Occurring Parkinson’s Disease Raises the Need for Nonhuman Primate in Neurodegenerative Diseases Research”, Neuroscience Bulletin, 2021, 37(8):1267-1269.
  20. Tremblay S, Acker L, Afraz A, et al., “An Open Resource for Non-human Primate Optogenetics”. Neuron. 2020, 108(6):1075-1090.e6.
  21. Chunshan Deng, Hong Yuan, Ji Dai*. “Behavioral Manipulation by Optogenetics in the Nonhuman Primate”, The Neuroscientist, 2018, 24(5): 526-539.
  22. Ji Dai, Yi Wang. “Contrast coding in the primary visual cortex depends on temporal contexts”, European Journal of Neuroscience. 2018, 47(8): 947-58.
  23. Bo Zhang, Ji Dai*, Tao Zhang. “NeoAnalysis: A Python-Based Toolbox for Quick Electrophysiological Data Processing and Analysis”. Biomedical Engineering Online. 2017, 16:129.
  24. Ji Dai*, Tao Zhang. “The progress of optogenetic studies in nonhuman primates”, Progress in Biochemistry and Biophysics, 2016, 43(4): 354-360.
  25. Ji Dai, Ilker Ozden, Daniel I. Brooks, Fabien Wagner, Travis May, Naubahar Agha, Benjamin Brush, David Borton, Arto V. Nurmikko, David L. Sheinberg “Modified toolbox for optogenetics in the nonhuman primate”, Neurophotonics, 2015, 2(3), 031202.
  26. Ji Dai, Daniel I. Brooks, David L. Sheinberg. “Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates”. Current Biology, 2014 Jan 6;24(1):63-9.
  27. Ji Dai and Yi Wang. “Representation of Surface Luminance and Contrast in Primary Visual Cortex”, Cerebral Cortex. 2012, 22(4):776-87.