Research

The morphology and composition of individual neuron will change during neural development or neural plasticity. The dynamics of cytoskeleton play a pivotal role in morphological development of neurons and in structural changes of adult neurons. Our current interests are focus on: (1) identify and elucidate key modulators responsible for cytoskeleton dynamics during neuronal development and neurodevelopment disorders; (2) elucidating the regulation of cytoskeleton dynamics by several extracellular signaling pathways during synapse formation, elimination, and neural plasticity in early stage of neurodegenerative diseases.

Biography

Associated investigator at SIAT, CAS since 2017.
2014-2017, HKUST Shenzhen Research Institute, Research & Project Manager.
2012-2014, Jinan University, Postdoc.
2009-2012, Jinan University, PhD.
2005-2008, Peking Union Medical College, MPhil.
2001-2005, Lanzhou University, BSc in Biology.

Selected publications

(^#equal contribution, *corresponding author)

1. Yijing Chen^#, Yinhu Li^#, Yingying Fan, Shuai Chen, Li Chen, Yuewen Chen, Yu Chen*. (2024) Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice. Gut Microbes 16(1):2302310.
2. Qiang Fu, Rui Qiu, Lei Chen, Yuewen Chen*, Wen Qi*, Yong Cheng. (2023) Music prevents stress-induced depression and anxiety-like behavior in mice. Translational Psychiatry 13(1):317.
3. Yang Du, Rui Qiu, Lei Chen, Yuewen Chen, Zhifeng Zhong, Peng Li, Fangcheng Fan*, Yong Cheng*. (2023) Identification of serum exosomal metabolomic and proteomic profiles for remote ischemic preconditioning. Journal of Translational Medicine 21(1):241.
4. Yuewen Chen^#, Zhenyan Xu^#, Jing Chen^#, Yue Qiu, Lin Yuan, Peng Liu, Jing Duan, Li Chen*, Yu Chen*. (2022) Coronin 2B Regulates neuronal migration via Rac1-dependent multipolar–bipolar transition. Journal of Neuroscience 43 (2): 211-220.
5. Yinhu Li^#, Yijing Chen^#, Yingying Fan, Yuewen Chen, Yu Chen*. (2023) Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice. Gut Microbes 15(1):2172672.
6. Xiaopu Zhou, Yu Chen, Fanny C F Ip, Yuanbing Jiang, Han Cao, Ge Lv, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M N Lo, Estella P S Tong; Alzheimer’s Disease Neuroimaging Initiative; Vincent C T Mok, Timothy C Y Kwok, Qihao Guo, Kin Y Mok, Maryam Shoai, John Hardy, Lei Chen, Amy K Y Fu, Nancy Y Ip*. (2023) Deep learning-based polygenic risk analysis for Alzheimer's disease prediction. Communications Medicine 3(1):49.
7. Mingfeng Guan^#, Yue Chai^#, Ran Yi, Yuewen Chen, Jacque P.K. Ip d, Tao Ye*, Yu Chen*. (2022) Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR /Cas9 system. Stem Cell Research 66:103000.
8. Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C. F. Ip, Vicky M. N. Chau, Shun-Fat Lau, Wei Wu, Daniel Y. K. Wong, Heukjin Seo, Wing-Yu Fu, Nicole C. H. Lai, Yuewen Chen, Yu Chen, Estella P. S. Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Maryam Shoai, Benoit Lehallier, Patricia Morán Losada, Eleanor O’Brien, Tenielle Porter, Simon M. Laws, John Hardy, Tony Wyss-Coray, Colin L. Masters, Amy K. Y. Fu*, Nancy Y. Ip*. (2022) An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature Aging 2: 616–634.
9. Han Cao, Xiaopu Zhou, Yu Chen, Fanny C F Ip, Yuewen Chen, Nicole C H Lai, Ronnie M N Lo, Estella P S Tong, Vincent C T Mok, Timothy C Y Kwok, Alzheimer’s Disease Neuroimaging Initiative; Amy K Y Fu, Nancy Y Ip*. (2022) Association of SPI1 haplotypes with altered SPI1 gene expression and Alzheimer's disease risk. Journal of Alzheimer’s Disease 86(4):1861-1873.
10. Xueqi Qu, Li Lin, Wanying Yi, Changyu Sun, Yuewen Chen, Yu Chen*. (2022) Early changes in transcriptomic profiles in synaptodendrosomes reveal aberrant synaptic functions in Alzheimer’s disease. International Journal of Molecular Sciences 23(16): 8888.
11. Yangyang Duan^#, Tao Ye^#, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K Y Fu, Viviana Gradinaru, Nancy Y Ip*. (2021) Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice. Nature Biomedical Engineering 6(2):168-180.
12. Tao Ye, Yangyang Duan, Hayley W S Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K Y Fu, Nancy Y Ip*. (2021) Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Communications Biology 4(1):195.
13. Lin Yuan, Wanying Yi, Changyu Sun, Shuangshuang Ma, Jiali Wang, Saijuan Liu, Yijing Chen, Yuewen Chen*, Yu Chen*. (2021) EphB2 activates CREB-dependent expression of Annexin A1 to regulate dendritic spine morphogenesis. Biochemical and Biophysical Research Communications 584:107-115.
14. Li Ouyang^#, Yu Chen^#, Ye Wang, Yuewen Chen, Amy K Y Fu, Wing-Yu Fu Nancy Y Ip*. (2020) p39-associated Cdk5 activity regulates dendritic morphogenesis. Scientific Reports 10(1):18746.
15. Yuewen Chen^#, Jinying Xu^#, Yulin Zhang, Shuangshuang Ma, Wanying Yi, Saijuan Liu, Xiaojun Yu, Jiali Wang, Yu Chen*. (2020) Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. FEBS Letters 594(18):2975-2987.
16. Xiaopu Zhou, Yu Chen, Fanny C F Ip, Nicole C H Lai, Yolanda Y T Li, Yuanbing Jiang, Huan Zhong, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M N Lo, Kit Cheung, Estella P S Tong, Ho Ko, Maryam Shoai, Kin Y Mok, John Hardy, Vincent C T Mok, Timothy C Y Kwok, Amy K Y Fu, Nancy Y Ip*. (2020) Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population. Alzheimer’s＆Dementia (Amsterdam Netherlands) 12(1):e12074.
17. Yuewen Chen^#*, Jinying Xu^#, Xiaopu Zhou, Saijuan Liu, Yulin Zhang, Shuangshuang Ma, Amy K. Y. Fu, Nancy Y. Ip, Yu Chen*. (2019) Changes of protein phosphorylation are associated with synaptic functions during the early stage of Alzheimer's disease. ACS Chemical Neuroscience 10(9):3986-3996.
18. Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Alzheimer’s Disease Neuroimaging Initiative, Paola Giusti-Rodríguez, Patrick F. Sullivan, John Hardy, Amy K. Y. Fu, Yun Li, Nancy Y. Ip. (2019) Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nature Communications 10(1):3310.
19. Xiaopu Zhou^#, Yu Chen^#, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo*, Nancy Y. Ip*, for the Alzheimer’s Disease Neuroimaging Initiative. (2018) Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis, Proceedings of the National Academy of Sciences of the United States of America 115(8): 1697–1706.
20. Yuewen Chen, Fanny C.F. Ip, Lei Shi, Zhe Zhang, Huibin Tang, Yu Pong Ng, Wen-Cai Ye, Amy K.Y. Fu, Nancy Y. Ip. (2014) Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton, Journal of Neuroscience 34(7):2413–21.
21. Yangui Xiao^#, Yinghui Peng^#, Jun Wan^#, Genyun Tang, Yuewen Chen, Jing Tang, Wen-Cai Ye, Nancy Y. Ip, Lei Shi. (2013) The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics, Journal of Biological Chemistry 288(27): 20034–20045.
22. Yu Pong Ng^#, Yuewen Chen^#, Yueqing Hu, Fanny C. F. Ip, Nancy Y. Ip. (2013) Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines. PLoS One 8(5): e63580.
23. Yuewen Chen^#, Qi Wu^#, Yong Shao, Jie Zhang, Ming Guan, Jun Wan, Bo Yu*, Wei Zhang*. (2012) Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis. International Journal of Immunogenetics 39(4):321-327.
24. Yuewen Chen^#, Jianwei Ye^#, Lingzhi Cao, Yong Zhang, Weibo Xia, Dahai Zhu. (2010) Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells. International Journal of Biochemistry & Cell Biology 42(12): 2072-2081.
25. Yuewen Chen^#, Linzhi Cao^#, Jianwei Ye, Dahai Zhu. (2009) Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin. Biochem Biophys Res Commun 388(1):112-116.