LIU Chang

LIU Chang

Ph.D, Principle Investigator
Investigates neural mechanisms of sleep, learning and memory
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Sleep, learning and memory are complex phenomena that are of great importance for survival. Although the quantity and quality of sleep have a profound impact on learning and memory, the exact mechanisms are not known. Daily learning experience was suggested to be helpful to improve sleep. However, the interaction mechanism between the two systems is rarely understood. To investigate the molecular and cellular basis of the interaction between sleep and memory, we will employ fruit fly Drosophila melanogaster as the animal model and apply multidisciplinary approach, including behavioral, genetic, anatomical and imaging techniques.


2019- Principle Investigator, SIAT CAS 2012-2019, Postdoctoral Fellow, Brandeis University
2007-2012, Ph.D. candidate, Kunming Institute of Zoology, CAS Joint Ph.D. candidate, Max-Planck Institute of Neurobiology
2004-2007, Research Assistant, Kunming Institute of Zoology, CAS
2003-2004, Biology teacher, Shijiazhuang No. 2 Middle School
1999-2003, BSc in Biology, Hebei Normal University

Selected publications

1.Peter Bronk, Elena A. Kuklin, Srinivas Corur-Shandilya, Chang Liu, Timothy D. Wiggin, Martha L. Reed, Eve Marder, Leslie C. Griffith. Regulation of Eag by calcium/calmodulin controls presynaptic excitability in Drosophila. Journal of Neurophysiology. 2018, 2018 May 1;119(5):1665-1680.

2.Timothy D. Wiggin, Patricia R. Goodwin, Nathan C. Donelson, Chang Liu, Leslie C. Griffith. A probabilistic model of sleep structure suggests a primary role for wake probability in overall sleep in Drosophila melanogaster. BioRxiv, 2018, doi:

3.Chang Liu, Paula R. Haynes, Nathan C. Donelson, Shani Aharon, Leslie C. Griffith. Sleep in populations of Drosophila melanogaster. eNeuro, 2015, 2 (4) e0071-15.2015

4.Zhiqiang Meng, Chang Liu, Chengyang Yu, Yuanye Ma. Transcranial direct current stimulation of the frontal-pariental-temporal area attenuates smoking behavior. Journal of Psychiatric Research, 2014 Jul; 54:19-25

5.Chang Liu, Pierre-Yves Plaçais, Nobuhiro Yamagata, Barret D. Pfeiffer, Yoshinori Aso,Anja B. Friedrich, Igor Siwanowicz, Gerald M. Rubin, Thomas Préat, Hiromu Tanimoto. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 2012, 488(7412):512-6