ResearchThe brain is the most complicated biological structure in the known universe, which consists of numerous interconnected neurons which form complex and highly ordered neural circuits. The coordinated neural activity of these neural circuits is the basis of higher brain functions such as perception, emotion, decision, memory, learning, and intelligence. However, there is a big gap between brain researches and the technologies available to use. Therefore, we use a combination of optogenetic probes, in vivo multi-sites electrophysiological recordings, pharmacogenetic manipulations of neuronal activity and virally based trans-synaptic tracing techniques for mapping neural connectivity as well as behavioral expression studies to understand the structures and functions of brain.
Research in this laboratory is mainly focused on: (1) developing new research tools and technologies for functional dissection of neural circuit, which including multi-functional optrode array techniques, electrochemical biosensors, electrode/neural tissue interface modifications, programmable optogenetic stimulators, neural information decoding of optical modulation and toolkit development; (2) dissecting the structure and function of specific neural circuits in neuropsychological diseases, such as epilepsy and emotion disorders.
Biography2018-present, Principle investigator and professor at SIAT CAS.
2012-2018, Investigator and associate professor at SIAT CAS.
2010-2012, Investigator and assistant professor at SIAT CAS.
2010, PhD in Physical Chemistry from Wuhan University.
1. Wang LL, Zhong C, Ke DN, Ye FM, Tu J, Wang LP*,Lu Y*, Ultra-soft and Highly Stretchable Hydrogel Optical Fibers for In Vivo Optogenetic Modulations. Advanced Optical Materials, 2018; in press (*Co-corresponding)
2. Wang LL, Huang K, Zhong C, Wang LP*, Lu Y*, Fabrication and modification of implantable optrode arrays for in vivo optogenetic applications. Biophysics Reports, 2018; 4: 82-93. (Cover Story) (*Co-corresponding)
3. Zhong C, Ke DN, Wang LL, Lu Y*, Wang LP*, Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface. Electrochemistry Communications, 2017; 79: 59-62. (*corresponding author)
4. Lu Y#, Zhong C#, Wang LL, Wei PF, He W, Huang K, Zhang Y, Zhan Y, Feng GP, Wang LP, Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures, Nature Communications, 2016;7:10962.
5. Zhong C, Zhang YY, He W, Wei PF, Lu Y*, Zhu Y, Liu L, Wang LP*. Multi-unit recording with iridium oxide modified stereotrodes in Drosophila melanogaster, Journal of Neuroscience Methods, 2014;222:218-29. (*corresponding author)
6. Lu Y, Li YL, Pan JQ, Wei PF, Liu N, Wu BF, Cheng JB, Lu CY, Wang LP*. Poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)-poly(vinyl alcohol)/poly (acrylic acid) interpenetrating polymer networks for improving optrode-neural tissue interface in optogenetics. Biomaterials, 2012;33:378-94.
7. Lu Y, Li T#, Zhao XQ, Li M, Cao YL, Yang HX, Duan YY*. Electrodeposited polypyrrole/carbon nanotubes composite films electrodes for neural interfaces. Biomaterials, 2010;31:5169-81. (#co-first author)
8. Lu Y, Wang DF, Li T, Zhao XQ, Cao YL, Yang HX, Duan YY*. Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface. Biomaterials, 2009; 30: 4143-51.
9. Lu Y, Wang TY, Cai ZX, Cao YL, Yang HX, Duan YY*. Anodically electrodeposited iridium oxide films microelectrodes for neural microstimulation and recording. Sensors & Actuators B: Chemical, 2009; 137: 334-9.
10. Lu Y, Cai ZX, Cao YL, Yang HX, Duan YY*. Activated iridium oxide films fabricated by asymmetric pulses for electrical neural micro stimulation and recording. Electrochemistry Communications, 2008; 10: 778-82.