ResearchThe morphology and composition of individual neuron will change during neural development or neural plasticity. The dynamics of cytoskeleton play a pivotal role in morphological development of neurons and in structural changes of adult neurons. Our current interests are focus on: (1) identify and elucidate key modulators responsible for cytoskeleton dynamics during neuronal development and neurodevelopment disorders; (2) elucidating the regulation of cytoskeleton dynamics by several extracellular signaling pathways during synapse formation, elimination, and neural plasticity in early stage of neurodegenerative diseases.
BiographyAssociated investigator at SIAT, CAS since 2017.
2014-2017, HKUST Shenzhen Research Institute, Research & Project Manager.
2012-2014, Jinan University, Postdoc.
2009-2012, Jinan University, PhD.
2005-2008, Peking Union Medical College, MPhil.
2001-2005, Lanzhou University, BSc in Biology.
Selected publications1.Zhou X, Chen Y, Mok KY, Zhao Q, Chen K, Chen Y, Hardy J, Li Y, Fu AKY, Guo Q, Ip NY. Alzheimer’s Disease Neuroimaging Initiative. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences, 115(8):1697-1706, 2018.
2. Chen Y, Liang Z, Fei E, Chen Y, Zhou X, Fang W, Fu WY, Fu AK, Ip NY. Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLoS One, 23;10(7):e0133115, 2015
3.Chen Y, Ip FC, Shi L, Zhang Z, Tang H, Ng YP, Ye WC, Fu AK, Ip NY, Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton, J Neurosci, 34(7):2413–21, 2014
4.Xiao Y, Peng Y, Wan J, Tang G, Chen Y, Tang J, Ye WC, Ip NY, Shi L, The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics, J Biol Chem, 288(27):20034-45, 2013
5.Ng YP#, Chen Y#, Hu Y, Ip FC, Ip NY, Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines, PLoS One, 16;8(5):e63580, 2013
6.Chen Y#, Wu Q#, Shao Y, Zhang J, Guan M, Wan J, Yu B, Zhang W, Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis, Int J Immunogenet, 39(4):321-7, 2012
7.Yu B#, Chen Y#, Wu Q, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Wan J, Zhang W, The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population. Clin Rheumatol, 30(4):521-7, 2011
8.Chen Y#, Ye J#, Cao L, Zhang Y, Xia W, Zhu D, Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells. Int J Biochem Cell Biol, 42 (12): 2072-81, 2010
9.Chen Y#, Cao L#, Ye J, Zhu D, Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin, Biochem Biophys Res Commun, 388: 112-6, 2009