ResearchIn healthy humans, physiological parameters, such as body temperature and blood pressure, are tightly controlled by the central nervous system (CNS) and maintained in a balanced condition termed homeostasis. It is believed that the metabolic homeostasis is achieved by feedback loops consisting of sensors, homeostats and effectors. In recent years, growing evidence suggests that the brain is the key hub which orchestrates multiple homeostatic processes. Specific neurons function as homeostats within the brain: they compute signals arising from peripheral sensors and send efferent controls to peripheral effectors. However, the locations of homeostats, their molecular identity, and their connections to the sensors and the effectors remains largely unknown. With the help of modern genetic, anatomical and neural circuit mapping tools, it is possible to dissect the pathways underling central control over homeostatic processes. My research will be focused on following areas: (1) genetic dissection of CNS cell types and circuits controlling homeostatic processes; (2) profiling of CNS cells during homeostasis and homeostatic breakdown; (3) methods to restore homeostasis in diseases; (4) intrinsic interactions between homeostatic processes.
BiographyPrincipal investigator at SIAT CAS since 2017
2013-2017, Postdoc Researcher, University of Heidelberg
2008-2012, The European Molecular Biology Laboratory, Monterotondo / Heidelberg, PhD.
2005-2007, Charité-Universitätsmedizin Berlin, MSc
2001-2005, Peking University, BSc
1. Kun Song*, Hong Wang*, Gretel B Kamm*, Jörg Pohle, Fernanda de Castro Reis, PaulHeppenstall, Hagen Wende, and Jan Siemens. The trpm2 channel is a hypothalamic heatsensor that limits fever and can drive hypothermia. * denotes equal contribution. Science, Aug2016.
2.Laura Batti, MayyaSundukova, Emanuele Murana, SofiaPimpinella, Fernanda De Castro Reis,FrancescaPagani, Hong Wang, Eloisa Pellegrino, Emerald Perlas, Silvia Di Angelantonio,DavideRagozzino, and Paul A Heppenstall. Tmem16f regulates spinal microglial function inneuropathic pain states. Cell Rep, 15(12):2608–2615, Jun 2016.
3.Hong Wang, Melanie Schupp, Sandra Zurborg, and Paul A Heppenstall. Residues in the poreregion of drosophila transient receptor potential a1 dictate sensitivity to thermal stimuli. JPhysiol, 591(1):185–201, Jan 2013.
4.Hong Wang and Jan Siemens. Trp ion channels in thermosensation, thermoregulation andmetabolism. Temperature (Austin), 2(2):178–187, 2015.