Research

My current research is focused on the technological developments of multiphoton microscopy to assess neuronal physiology, cerebral blood flow and oxygen metabolism, and neurovascular coupling in preclinical models. My long-term research goals include 1) developing advanced optical imaging tools and methods, and 2) applying them to study brain physiology and function.

Biography

2020-Present, Associate Investigator, Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China.
2015-2019, Postdoc, Massachusetts General Hospital, Harvard Medical School. 2014, Ph.D. in Biomedical Engineering, École Polytechnique, University of Montreal.

Selected publications

1. Baoqiang Li(#), Xuecong Lu(#), Mohammad Moeini, Sava Sakadžić, Eric Thorin, and Frederic Lesage(*), “Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation,” PLoS One, 2019.

2. Baoqiang Li(#), Tatiana V. Esipova(#), Ikbal Sencan, Kıvılcım Kılıç, Buyin Fu, Michele Desjardins, Mohammad Moeini, Sreekanth Kura, Mohammad A. Yaseen, Frederic Lesage, Leif Østergaard, Anna Devor, David A. Boas, Sergei A. Vinogradov, and Sava Sakadžić(*), “More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction,” eLife, 2019.

3. Baoqiang Li(*), Ryo Ohtomo, Martin Thunemann, Stephen R Adams, Jing Yang, Buyin Fu, Mohammad A Yaseen, Chongzhao Ran, Jonathan R. Polimeni, David A. Boas, Anna Devor, Eng H. Lo, Ken Arai, and Sava Sakadžić, “Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion,” J. Cereb. Blood Flow Metab., 2019.

4. Baoqiang Li(*), Hui Wang, Buyin Fu, Ruopeng Wang, Sava Sakadžić, and David Boas, “Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography,” J. Biomed. Opt., 2017.

5. Baoqiang Li(*), Jongwhan Lee, David Boas, and Frederic Lesage, “Contribution of low- and high-flux capillaries to slow hemodynamic fluctuations in the cerebral cortex of mice,” J. Cereb. Blood Flow Metab., 2016.