ResearchWe are interested in the brain mechanisms underlying visual attention, working memory and eye movement etc. Impairments in these mechanisms have been associated with many brain disorders such as ADHD, autism and schizophrenia. By studying the visual systems in nonhuman primates, we have shown that visual attention is mediated by complex interactions between association cortex, visual cortex and sub-cortex areas. Our long-term research goal is to characterize the mechanisms underlying these inter-area communications and local interactions within an area, then apply this scientific knowledge to help to understand the mechanisms of brain disorders. We use a multi-disciplinary approach, including electrophysiology, behavior, optogenetics, neuronal imaging to study these questions in alert monkeys.
Biography2014- present, Principal investigator at SIAT CAS since 2014.
2005-2014, Research Scientist at MIT McGovern Institute for Brain Research
2000, Peking Union Medical College, PhD.
1995, Zhejiang University, BEng.
Selected publications1. Mao X, Li W, He H, Xian B, Zeng M, Huihui Zhou, Niu L, and Chen G. Object Extraction in Cluttered Environments via a P300-Based IFCE. Computational Intelligence and Neuroscience, 2017:5468208, 2017
2. Huihui Zhou, Schafer Robert J, Desimone R. Pulvinar-Cortex Interactions in Vision and Attention. Neuron, 89(1): 209-20. 2016.
3. Jennings CG, Landman R, Zhou Y, Sharma J, Hyman J, Movshon JA, Qiu Z, Roberts AC, Roe AW, Wang X, Huihui Zhou, Wang L, Zhang F, Desimone R, Feng G. Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 19: 1123-30, 2016.
4. Li M, Li W and Huihui Zhou. Increasing N200 potentials via visual stimulus depicting humanoid robot behavior. International J.Neural Sys. 26: 1550039, 2016
5. Xue Han, Brian Y. Chow, Huihui Zhou, Nathan C. Klapoetke, Amy Chuong, Reza Rajimehr, Aimei Yang, Michael V. Baratta, Jonathan Winkle, Robert Desimone and Edward S. Boyden. A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Front. Syst. Neurosci.5: 18. doi: 10.3389/fnsys.2011.00018, 2011.
6. Huihui Zhou, Robert Desimone. Feature-Based Attention in the Frontal Eye Field and Area V4 during Visual Search. Neuron. 70: 1205-17, 2011.
7. Georgia G. Gregoriou, Stephen J. Gotts, Huihui Zhou, Robert Desimone. High-frequency, long-range coupling between prefrontal and visual cortex during attention. Science. 324: 1207-10, 2009.
8. Xue Han, Xiaofeng Qian, Jacob G. Bernstein, Huihui Zhou, Giovanni Talei Franzesi, Patrick Stern, Roderick T. Bronson, Ann M. Graybiel, Robert Desimone and Edward S. Boyden. Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron.62: 191-8, 2009.
9. Huihui Zhou and Kirk G. Thompson. Cognitively directed spatial selection in the frontal eye field in anticipation of visual stimuli to be discriminated. Vision Research. 49: 1205-1215, 2009.
10. Georgia G. Gregoriou, Stephen J. Gotts, Huihui Zhou, Robert Desimone. Long-range neural coupling through synchronization with attention. Prog Brain Res. 176: 35-45, 2009.
11. Dora E. Angelaki, Huihui Zhou, and Min We. Foveal versus full-field visual stabilization strategies for translational and rotational head movements. J. Neurosci.,23: 1104 1108, 2003.
12. Huihui Zhou, Min Wei, and Dora E. Angelaki. Motor scaling by viewing distance of early visual motion signals during smooth pursuit. J. Neurophysiol, 88: 2880 2885, 2002.
13. Huihui Zhou, Yi-Kuan Xie. Excitatory connection between spinal motoneurons in adult rats. Chinese Medical Science Journal. 15: 35-39, 2000.